Microbiology Spectrum (Jul 2025)
One Health study of mobile colistin resistance (mcr) in Salmonella enterica in Canada, 2017–2022
- Ketna Mistry,
- David Thumbi,
- Xiao Rui Li,
- Audrey Charlebois,
- Brent P. Avery,
- Anne E. Deckert,
- Ashley C. Cormier,
- Colleen Murphy,
- Ashley Kearney,
- Jennifer Campbell,
- Sara Christianson,
- David C. Alexander,
- Sameh El Bailey,
- Sadjia Bekal,
- Linda Chui,
- Xiaofeng Ding,
- Tanis Dingle,
- David Haldane,
- Linda Hoang,
- Jessica Minion,
- Samir Patel,
- George Zahariadis,
- Celine Nadon,
- Michael R. Mulvey,
- Carolee A. Carson,
- Richard J. Reid-Smith,
- Amrita Bharat
Affiliations
- Ketna Mistry
- National Microbiology Laboratory Branch, Public Health Agency of Canada, Guelph, Ontario, Canada
- David Thumbi
- National Microbiology Laboratory Branch, Public Health Agency of Canada, Guelph, Ontario, Canada
- Xiao Rui Li
- National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
- Audrey Charlebois
- National Microbiology Laboratory Branch, Public Health Agency of Canada, Saint-Hyacinthe, Québec, Canada
- Brent P. Avery
- Centre for Food-borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Guelph, Ontario, Canada
- Anne E. Deckert
- Centre for Food-borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Guelph, Ontario, Canada
- Ashley C. Cormier
- Centre for Food-borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Guelph, Ontario, Canada
- Colleen Murphy
- Centre for Food-borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Guelph, Ontario, Canada
- Ashley Kearney
- National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
- Jennifer Campbell
- National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
- Sara Christianson
- National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
- David C. Alexander
- Cadham Provinical Laboratory, Diagnostic Services, Shared Health, Winnipeg, Manitoba, Canada
- Sameh El Bailey
- Department of Laboratory Medicine, Horizon Health Network, Saint John, New Brunswick, Canada
- Sadjia Bekal
- Département de Bactériologie, Laboratoire de santé publique du Québec, Sainte-Anne-de-Bellevue, Québec, Canada
- Linda Chui
- Alberta Precision Laboratories, Public Health Laboratory, Edmonton, Alberta, Canada
- Xiaofeng Ding
- Provincial Laboratory Services, Queen Elizabeth Hospital, Charlottetown, Prince Edward Island, Canada
- Tanis Dingle
- Alberta Precision Laboratories, Public Health Laboratory, Calgary, Alberta, Canada
- David Haldane
- Department of Pathology and Laboratory Medicine, Queen Elizabeth II Health Sciences Centre, Halifax, Nova Scotia, Canada
- Linda Hoang
- Public Health Laboratory, British Columbia Center for Disease Control, Vancouver, British Columbia, Canada
- Jessica Minion
- Saskatchewan Health Authority, Department of Laboratory Medicine, Roy Romanow Provincial Laboratory, Regina, Saskatchewan, Canada
- Samir Patel
- Public Health Ontario Laboratory, Public Health Ontario, Toronto, Ontario, Canada
- George Zahariadis
- Department of Pathology and Laboratory Medicine, Newfoundland and Labrador Public Health and Microbiology Laboratory, St. John’s, Newfoundland and Labrador, Canada
- Celine Nadon
- National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
- Michael R. Mulvey
- National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
- Carolee A. Carson
- Centre for Food-borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Guelph, Ontario, Canada
- Richard J. Reid-Smith
- Centre for Food-borne, Environmental and Zoonotic Infectious Diseases, Public Health Agency of Canada, Guelph, Ontario, Canada
- Amrita Bharat
- National Microbiology Laboratory Branch, Public Health Agency of Canada, Winnipeg, Manitoba, Canada
- DOI
- https://doi.org/10.1128/spectrum.02156-24
- Journal volume & issue
-
Vol. 13,
no. 7
Abstract
ABSTRACT Colistin is a last-resort treatment for highly drug-resistant bacterial infections. Of 47,184 Salmonella isolates collected from 2017 to 2022 in Canada from human and animal/food sources, mobile colistin resistance (mcr) variants conferring colistin resistance were detected exclusively in humans (n = 15). These variants were mcr-1.1 (n = 7), mcr-3.1 (n = 5), mcr-3.2 (n = 2), and mcr-1.2 (n = 1). The most common mcr-containing serotypes were I 4,[5],12:i:- (n = 8) and Typhimurium (n = 3). The proportion of Salmonella carrying mcr genes remains low in Canada (0.03%).IMPORTANCEColistin can be used in combination with other drugs as salvage therapy for extensively drug-resistant infections. If mobile colistin resistance (mcr) becomes widely disseminated in Enterobacterales, colistin will no longer be an option for salvage therapy in otherwise untreatable infections. While colistin is not commonly used to treat human Salmonella infections, Salmonella represents an important reservoir of mcr genes that may be transmitted to other gram-negative bacteria. Our aim was to determine the occurrence of mcr genes in Salmonella isolates collected from humans, food animals, and retail meats in Canada.
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