Macrophage-derived IGF-1 protects the neonatal intestine against necrotizing enterocolitis by promoting microvascular development

Xiaocai Yan; Elizabeth Managlia; You-Yang Zhao; Xiao-Di Tan; Isabelle G. De Plaen

doi:10.1038/s42003-022-03252-9

Communications Biology (Apr 2022)

Macrophage-derived IGF-1 protects the neonatal intestine against necrotizing enterocolitis by promoting microvascular development

Xiaocai Yan,
Elizabeth Managlia,
You-Yang Zhao,
Xiao-Di Tan,
Isabelle G. De Plaen

Affiliations

Xiaocai Yan: Division of Neonatology, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine
Elizabeth Managlia: Division of Neonatology, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine
You-Yang Zhao: Program for Lung and Vascular Biology, Stanley Manne Children’s. Research Institute, Ann & Robert H. Lurie Children’s Hospital of Chicago
Xiao-Di Tan: Center for Intestinal and Liver Inflammation Research, Stanley Manne Children’s. Research Institute, Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine
Isabelle G. De Plaen: Division of Neonatology, Department of Pediatrics, Ann & Robert H. Lurie Children’s Hospital of Chicago, Northwestern University Feinberg School of Medicine

DOI: https://doi.org/10.1038/s42003-022-03252-9
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 13

Abstract

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This study highlights the impact of macrophage-derived IGF-1 on the microvascular development in the neonatal intestine and a resulting protective effect against necrotizing enterocolitis.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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