Nature Communications (Jun 2020)
ARS2/MAGL signaling in glioblastoma stem cells promotes self-renewal and M2-like polarization of tumor-associated macrophages
- Jinlong Yin,
- Sung Soo Kim,
- Eunji Choi,
- Young Taek Oh,
- Weiwei Lin,
- Tae-Hoon Kim,
- Jason K. Sa,
- Jun Hee Hong,
- Se Hwan Park,
- Hyung Joon Kwon,
- Xiong Jin,
- Yeonhee You,
- Ji Hye Kim,
- Hyunggee Kim,
- Jaekyoung Son,
- Jeongwu Lee,
- Do-Hyun Nam,
- Kui Son Choi,
- Bingyang Shi,
- Ho-Shin Gwak,
- Heon Yoo,
- Antonio Iavarone,
- Jong Heon Kim,
- Jong Bae Park
Affiliations
- Jinlong Yin
- Henan and Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University
- Sung Soo Kim
- Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center
- Eunji Choi
- Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center
- Young Taek Oh
- Rare Cancer Branch, Research Institute and Hospital, National Cancer Center
- Weiwei Lin
- Rare Cancer Branch, Research Institute and Hospital, National Cancer Center
- Tae-Hoon Kim
- Rare Cancer Branch, Research Institute and Hospital, National Cancer Center
- Jason K. Sa
- Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University
- Jun Hee Hong
- Rare Cancer Branch, Research Institute and Hospital, National Cancer Center
- Se Hwan Park
- Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center
- Hyung Joon Kwon
- Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center
- Xiong Jin
- Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University
- Yeonhee You
- Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center
- Ji Hye Kim
- Department of Biomedical Sciences, University of Ulsan College of Medicine
- Hyunggee Kim
- Department of Biotechnology, School of Life Sciences and Biotechnology, Korea University
- Jaekyoung Son
- Department of Biomedical Sciences, University of Ulsan College of Medicine
- Jeongwu Lee
- Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic
- Do-Hyun Nam
- Department of Health Sciences and Technology, SAIHST, Sungkyunkwan University
- Kui Son Choi
- Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center
- Bingyang Shi
- Henan and Macquarie University Joint Centre for Biomedical Innovation, School of Life Sciences, Henan University
- Ho-Shin Gwak
- Department of Cancer Control and Population Health, Graduate School of Cancer Science and Policy, National Cancer Center
- Heon Yoo
- Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center
- Antonio Iavarone
- Institute for Cancer Genetics, Columbia University Medical Center
- Jong Heon Kim
- Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center
- Jong Bae Park
- Department of Cancer Biomedical Science, Graduate School of Cancer Science and Policy, National Cancer Center
- DOI
- https://doi.org/10.1038/s41467-020-16789-2
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 15
Abstract
How glioblastoma stem cells (GSCs) and tumor-associated macrophages (TAMs) interact to promote progression of glioblastoma multiforme (GBM) is currently unclear. Here, the authors demonstrate a role for the ARS2/MAGL signalling in regulating self-renewal and tumorigenicity of GSCs and M2-like TAM polarization.
