Evaluation of Antiphospholipid Antibodies and Activated Partial Thromboplastin Time in Women with Adverse Outcome of Pregnancy

Abstract

Adverse outcome of pregnancy is a potentially dangerouscomplication of conception and affects 15-20% of pregnancies.According to recent studies increased level of bloodantiphospholipids antibodies, if accompanied by predisposingfactors, can be an adverse event in human pregnancy.The aim of the present study was to compare the maternalserum levels of anticardiolipin and antiphosphatidyl serine,and partial thromboplastin time between patients with adverseoutcome of pregnancy and matched subjects with normalpregnancy. Serum levels of anticardiolipin and antiphosphatidylserine and activated partial thromboplastin timewere measured in 150 women with adverse pregnancy outcomeand 150 matched women with normal pregnancy aftera gestational age of 10 weeks. Data on maternal age, age ofpregnancy, serum levels of anticardiolipin and antiphosphatidylserine, and activated partial thromboplastin timewere collected and compared by Student’s t or χ 2 tests. Theage of mothers in the two groups were 25.86±5.90 and27.09±5.63 years (P=0.67), and the age of pregnancies were29.34±5.12 and 28.17±7.03 (P=0.1) weeks in the control andpatient groups, respectively. Positive levels of serum anticardiolipinand antiphosphatidyl serine antibodies, and activatedpartial thromboplastin time for the control and patient groupswere 14.3% versus 85.7% (P=0.002), 15.2 % versus 84.8 %(P=0.003), and 23.1 % versus 76.9% (P=0.001), respectively.The findings suggest that positive levels of serum antiphospholipidsare associated with adverse outcome of pregnancyin the study population.Iran J Med Sci 2010; 35(4): 315-318.

Keywords

• Activated partial thromboplastin time
• phosphatidyl serines
• anticardiolipin
• normal pregnancy