Cell Transplantation (Jan 2014)
Consensus of Clinical Neurorestorative Progress in Patients with Complete Chronic Spinal Cord Injury
- Hongyun Huang,
- Tiansheng Sun,
- Lin Chen,
- Gustavo Moviglia,
- Elena Chernykh,
- Klaus Von Wild,
- Haluk Deda,
- Kyung-Sun Kang,
- Anand Kumar,
- Sang Ryong Jeon,
- Shaocheng Zhang,
- Giorgio Brunelli,
- Albert Bohbot,
- Maria Dolors Soler,
- Jianjun Li,
- Alexandre Fogaça Cristante,
- Haitao Xi,
- Gelu Onose,
- Helmut Kern,
- Ugo Carraro,
- Hooshang Saberi,
- Hari Shanker Sharma,
- Alok Sharma,
- Xijing He,
- Dafin Muresanu,
- Shiqing Feng,
- Ali Otom,
- Dajue Wang,
- Koichi Iwatsu,
- Jike Lu,
- Adeeb Al-Zoubi
Affiliations
- Hongyun Huang
- Center of Neurorestoratology, Beijing Rehabilitation Hospital, Capital Medical University, Beijing, China
- Tiansheng Sun
- Department of Orthopedics, Beijing Army General Hospital, Beijing, China
- Lin Chen
- Medical Center, Tsinghua University, Beijing, China
- Gustavo Moviglia
- Centro de Investigación en Ingeniería de Tejidos y Terapia Celular, Universidad Maimónides, Buenos Aires, Argentina
- Elena Chernykh
- Institute of Clinical Immunology, Siberian Division of the Russian Academy of Medical Sciences, Institute of Traumatology and Orthopedics, Novosibirsk, Russia
- Klaus Von Wild
- Medical Faculty, Westfälische Wilhelms University, Münster, North Rhine-Westphalia, Germany
- Haluk Deda
- Department of Neurosurgery and Neurology, Akay Hospital, Ankara, Turkey
- Kyung-Sun Kang
- Adult Stem Cell Research Center, Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, Korea
- Anand Kumar
- Department of Stem Cells, Lifeline Institute of Regenerative Medicine, Rajiv Gandhi Salai, Perungudi, Chennai, India
- Sang Ryong Jeon
- Department of Neurological Surgery, ASAN Medical Center, University of Ulsan College of Medicine, Seoul, Korea
- Shaocheng Zhang
- Department of Orthopedics, Changhai Hospital, Shanghai, China
- Giorgio Brunelli
- Fondazione Midollo Spinale, Brescia, Italy
- Albert Bohbot
- Laboratoire de Recherches sur le LASERPONCTURE, Espace Minerve, France
- Maria Dolors Soler
- Hospital de Neurorehabilitació, Institut Guttmann, Camí Can Ruti s/n. Barcelona, Spain
- Jianjun Li
- Department of Spinal and Neural Function Reconstruction, China Rehabilitation Research Center, Beijing, China
- Alexandre Fogaça Cristante
- Institute of Orthopedics and Traumatology, Hospital das Clínicas, University of São Paulo School of Medicine, São Paulo, Brazil
- Haitao Xi
- Department of Neurorestoratology, Jingdong Zhongmei Hospital, Yanjiao, Beijing East, China
- Gelu Onose
- The Teaching Emergency Hospital Bagdasar-Arseni (TEHBA), Bucharest, Romania
- Helmut Kern
- Ludwig Boltzmann Institute of Electrical Stimulation and Physical Rehabilitation, Department of Physical Medicine and Rehabilitation, Wilhelminenspital Wien, Austria
- Ugo Carraro
- Laboratory of Translational Myology, Department of Biomedical Sciences, University of Padua, Italy
- Hooshang Saberi
- Department of Neurosurgery, Imam Khomeini Hospital, Tehran University of Medical Sciences, Iran
- Hari Shanker Sharma
- Laboratory of Cerebrovascular Research, Department of Surgical Sciences, Anaesthesiology and Intensive Care Medicine, University Hospital, Uppsala University, Sweden
- Alok Sharma
- Department of Neurosurgery, LTMG Hospital and LTM Medical College, Mumbai, India
- Xijing He
- Second Department of Orthopedics, The Second Affiliated Hospital, Medical School of Xi'an Jiaotong University, Xi'an, China
- Dafin Muresanu
- Department of Neurosciences, University of Medicine and Pharmacy “Iuliu Hatieganu,” Cluj-Napoca, Romania
- Shiqing Feng
- Orthopaedic Department of General Hospital of Tianjin Medical University, Tianjin, China
- Ali Otom
- Spinal Unit, King Hussein Medical Centre, Amman, Jordan
- Dajue Wang
- Midlands Centre for Spinal Injuries, Robert Jones and Agnes Hunt Orthopaedic Hospital, Oswestry, UK
- Koichi Iwatsu
- Department of Neurosurgery, Osaka University Medical School, Japan
- Jike Lu
- Department of Orthopaedic Surgery, Tarre Hospital, NSW, Australia
- Adeeb Al-Zoubi
- Department of Surgery, University of Illinois College of Medicine, Peoria, IL, USA
- DOI
- https://doi.org/10.3727/096368914X684952
- Journal volume & issue
-
Vol. 23
Abstract
Currently, there is a lack of effective therapeutic methods to restore neurological function for chronic complete spinal cord injury (SCI) by conventional treatment. Neurorestorative strategies with positive preclinical results have been translated to the clinic, and some patients have gotten benefits and their quality of life has improved. These strategies include cell therapy, neurostimulation or neuromodulation, neuroprosthesis, neurotization or nerve bridging, and neurorehabilitation. The aim of this consensus by 31 experts from 20 countries is to show the objective evidence of clinical neurorestoration for chronic complete SCI by the mentioned neurorestorative strategies. Complete chronic SCI patients are no longer told, “nothing can be done.” The clinical translation of more effective preclinical neurorestorative strategies should be encouraged as fast as possible in order to benefit patients with incurable CNS diseases. This manuscript is published as part of the International Association of Neurorestoratology (IANR) special issue of Cell Transplantation .
