Dietary Fish Oil and Zinc Reduced Plasma Prostaglandin E2 Content by Inhibiting Phospholipase A2 Production in Broilers

Abstract

Two-factor experiment was designed to examine from lipid metabolism, proinflammatory eicosanoids, and lipid peroxidation for investigating the effects of dietary oils and zinc levels of cardiovascular system of broilers. One hundred sixty 1-d-old male broilers were divided into 4 groups with 8 replicates of 5 birds fed one of the diets containing either corn oil or fish oil with one of 2 levels (75 mg/kg, 150 mg/kg) of zinc. Fish oil significantly decreased the levels of serum total cholesterol, triglyceride, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol of broilers, decreased the contents of plasma prostaglandin E2, thromboxane B2, and phospholipase A2 in broilers when compared with corn oil. Zn level did not alter lipid metabolism, but significantly affected eicosanoid synthesis and lipid peroxidation of broilers. Zinc at 150 mg/kg significantly decreased the contents of plasma prostaglandin E2, malondialdehyde, and phospholipase A2 in broilers when compared to zinc at 75 mg/Kg. There were significant interactions between oil sources and zinc levels on production of serum triglyceride, high density lipoprotein-cholesterol, plasma 6-keto- prostaglandin F1α, phospholipase A2 and malondialdehyde. In conclusion, fish oil improved lipid profiles, reduced proinflammatory eicosanoid contents by inhibiting phospholipase A2 production in broilers; while zinc reduced the contents of plasma malondialdehyde, phospholipase A2, and then decreased the concentration of prostaglandin E2 of broilers.

Keywords

• broiler
• corn oil
• fish oil
• lipid metabolism
• proinflammatory eicosanoid