Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases

Manav Kapoor; Michael J. Chao; Emma C. Johnson; Gloriia Novikova; Dongbing Lai; Jacquelyn L. Meyers; Jessica Schulman; John I. Nurnberger; Bernice Porjesz; Yunlong Liu; The Collaborative Study on the Genetics of Alcoholism (COGA); Tatiana Foroud; Howard J. Edenberg; Edoardo Marcora; Arpana Agrawal; Alison Goate

doi:10.1038/s41467-021-25392-y

Nature Communications (Aug 2021)

Multi-omics integration analysis identifies novel genes for alcoholism with potential overlap with neurodegenerative diseases

Manav Kapoor,
Michael J. Chao,
Emma C. Johnson,
Gloriia Novikova,
Dongbing Lai,
Jacquelyn L. Meyers,
Jessica Schulman,
John I. Nurnberger,
Bernice Porjesz,
Yunlong Liu,
The Collaborative Study on the Genetics of Alcoholism (COGA),
Tatiana Foroud,
Howard J. Edenberg,
Edoardo Marcora,
Arpana Agrawal,
Alison Goate

Affiliations

Manav Kapoor: Departments of Genetics and Genomic Sciences and Neuroscience, Icahn School of Medicine at Mount Sinai
Michael J. Chao: Departments of Genetics and Genomic Sciences and Neuroscience, Icahn School of Medicine at Mount Sinai
Emma C. Johnson: Department of Psychiatry, Washington University School of Medicine
Gloriia Novikova: Departments of Genetics and Genomic Sciences and Neuroscience, Icahn School of Medicine at Mount Sinai
Dongbing Lai: Department of Medical and Molecular Genetics, Indiana University School of Medicine
Jacquelyn L. Meyers: Department of Psychiatry, State University of New York, Downstate Medical Center
Jessica Schulman: Departments of Genetics and Genomic Sciences and Neuroscience, Icahn School of Medicine at Mount Sinai
John I. Nurnberger: Department of Psychiatry, Indiana University School of Medicine
Bernice Porjesz: Department of Psychiatry, State University of New York, Downstate Medical Center
Yunlong Liu: Department of Medical and Molecular Genetics, Indiana University School of Medicine
The Collaborative Study on the Genetics of Alcoholism (COGA)
Tatiana Foroud: Department of Medical and Molecular Genetics, Indiana University School of Medicine
Howard J. Edenberg: Department of Medical and Molecular Genetics, Indiana University School of Medicine
Edoardo Marcora: Departments of Genetics and Genomic Sciences and Neuroscience, Icahn School of Medicine at Mount Sinai
Arpana Agrawal: Department of Psychiatry, Washington University School of Medicine
Alison Goate: Departments of Genetics and Genomic Sciences and Neuroscience, Icahn School of Medicine at Mount Sinai

DOI: https://doi.org/10.1038/s41467-021-25392-y
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 12

Abstract

Read online

Alcohol use disorder and drinks per week both have been studied genetically and have different correlations with psychiatric diseases. Here the authors integrate multi-omics data to identify unique and shared variants, genes and pathways for alcohol use disorder and drinks per week.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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