Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas

Kun Do Rhee; Yanjie Wang; Johanna ten Hoeve; Linsey Stiles; Thao Thi Thu Nguyen; Xiangmei Zhang; Laurent Vergnes; Karen Reue; Orian Shirihai; Dean Bok; Xian-Jie Yang

doi:10.1038/s41467-022-34443-x

Nature Communications (Nov 2022)

Ciliary neurotrophic factor-mediated neuroprotection involves enhanced glycolysis and anabolism in degenerating mouse retinas

Kun Do Rhee,
Yanjie Wang,
Johanna ten Hoeve,
Linsey Stiles,
Thao Thi Thu Nguyen,
Xiangmei Zhang,
Laurent Vergnes,
Karen Reue,
Orian Shirihai,
Dean Bok,
Xian-Jie Yang

Affiliations

Kun Do Rhee: Stein Eye Institute, Department of Ophthalmology, University of California, Davide Geffen School of Medicine
Yanjie Wang: Stein Eye Institute, Department of Ophthalmology, University of California, Davide Geffen School of Medicine
Johanna ten Hoeve: Department of Molecular and Medical Pharmacology, University of California, Davide Geffen School of Medicine
Linsey Stiles: Department of Molecular and Medical Pharmacology, University of California, Davide Geffen School of Medicine
Thao Thi Thu Nguyen: Stein Eye Institute, Department of Ophthalmology, University of California, Davide Geffen School of Medicine
Xiangmei Zhang: Stein Eye Institute, Department of Ophthalmology, University of California, Davide Geffen School of Medicine
Laurent Vergnes: Department of Human Genetics, University of California, Davide Geffen School of Medicine
Karen Reue: Department of Human Genetics, University of California, Davide Geffen School of Medicine
Orian Shirihai: Department of Molecular and Medical Pharmacology, University of California, Davide Geffen School of Medicine
Dean Bok: Stein Eye Institute, Department of Ophthalmology, University of California, Davide Geffen School of Medicine
Xian-Jie Yang: Stein Eye Institute, Department of Ophthalmology, University of California, Davide Geffen School of Medicine

DOI: https://doi.org/10.1038/s41467-022-34443-x
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 15

Abstract

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Rhee et al. demonstrates that the potent neuroprotective agent CNTF significantly impacts metabolism of degenerating retinas, thus revealing cellular mechanisms underlying enhanced neuronal viability and providing insight for the ongoing CNTF clinical trials.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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