Nature Communications (Oct 2018)

IL-7 receptor blockade blunts antigen-specific memory T cell responses and chronic inflammation in primates

  • Lyssia Belarif,
  • Caroline Mary,
  • Lola Jacquemont,
  • Hoa Le Mai,
  • Richard Danger,
  • Jeremy Hervouet,
  • David Minault,
  • Virginie Thepenier,
  • Veronique Nerrière-Daguin,
  • Elisabeth Nguyen,
  • Sabrina Pengam,
  • Eric Largy,
  • Arnaud Delobel,
  • Bernard Martinet,
  • Stéphanie Le Bas-Bernardet,
  • Sophie Brouard,
  • Jean-Paul Soulillou,
  • Nicolas Degauque,
  • Gilles Blancho,
  • Bernard Vanhove,
  • Nicolas Poirier

DOI
https://doi.org/10.1038/s41467-018-06804-y
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 13

Abstract

Read online

Chronic inflammation often involves reactivation of memory adaptive immune. Here the authors show, using non-human primate models, that a single dose of anti-IL-7 receptor monoclonal antibody that exhibits antagonist but not agonist properties can reduce the frequency of antigen-specific T cell to help repress chronic skin inflammation.