Repeated topical paeoniflorin attenuates postoperative pain and accelerates cutaneous fibroblast proliferation in mice

Abstract

This study investigated whether the repeated topical paeoniflorin inhibits postoperative pain in mice. An incision of the plantar skin and underlying muscle of the hind paw elicits acute postoperative pain. Repeated topical paeoniflorin inhibited postoperative pain. An adenosine A1 receptor antagonist (DPCPX) attenuated the analgesic effect of paeoniflorin. Paeoniflorin treatment accelerated wound healing at the surgical site. Paeoniflorin accelerated fibroblast proliferation, which inhibited by DPCPX. These results suggest that the repeated topical paeoniflorin attenuates postoperative pain and accelerated wound healing through fibroblast proliferation, and the activation of adenosine A1 receptor is involved in the action of paeoniflorin.

Keywords

• Postoperative pain
• Paeoniflorin
• Fibroblasts