Interruption of post-Golgi STING trafficking activates tonic interferon signaling

Xintao Tu; Ting-Ting Chu; Devon Jeltema; Kennady Abbott; Kun Yang; Cong Xing; Jie Han; Nicole Dobbs; Nan Yan

doi:10.1038/s41467-022-33765-0

Nature Communications (Nov 2022)

Interruption of post-Golgi STING trafficking activates tonic interferon signaling

Xintao Tu,
Ting-Ting Chu,
Devon Jeltema,
Kennady Abbott,
Kun Yang,
Cong Xing,
Jie Han,
Nicole Dobbs,
Nan Yan

Affiliations

Xintao Tu: Department of Immunology, UT Southwestern Medical Center
Ting-Ting Chu: Department of Immunology, UT Southwestern Medical Center
Devon Jeltema: Department of Immunology, UT Southwestern Medical Center
Kennady Abbott: Department of Immunology, UT Southwestern Medical Center
Kun Yang: Department of Immunology, UT Southwestern Medical Center
Cong Xing: Department of Immunology, UT Southwestern Medical Center
Jie Han: Department of Immunology, UT Southwestern Medical Center
Nicole Dobbs: Department of Immunology, UT Southwestern Medical Center
Nan Yan: Department of Immunology, UT Southwestern Medical Center

DOI: https://doi.org/10.1038/s41467-022-33765-0
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 16

Abstract

Read online

Microbial DNA is recognized by the cGAS-STING pathway, which leads to a type I interferon response. Here authors show that a basal flux of interferon activation could also be triggered by interference with STING trafficking from the Golgi apparatus to the lysosomes.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

About the journal