Nature Communications (Oct 2018)

DUSP10 constrains innate IL-33-mediated cytokine production in ST2hi memory-type pathogenic Th2 cells

  • Takeshi Yamamoto,
  • Yusuke Endo,
  • Atsushi Onodera,
  • Kiyoshi Hirahara,
  • Hikari K. Asou,
  • Takahiro Nakajima,
  • Toshio Kanno,
  • Yasuo Ouchi,
  • Satoshi Uematsu,
  • Hiroshi Nishimasu,
  • Osamu Nureki,
  • Damon J. Tumes,
  • Naoki Shimojo,
  • Toshinori Nakayama

DOI
https://doi.org/10.1038/s41467-018-06468-8
Journal volume & issue
Vol. 9, no. 1
pp. 1 – 15

Abstract

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T helper 2 (Th2) cells and type 2 innate lymphoid cells (ILC2) respond differently to interleukin-33 (IL-33) stimulation. Here the authors show that a phosphatase, Dusp10, is expressed in Th2, but not ILC2, to dephosphorylate p38 kinase, reduce GATA3 transcription factor activity, and suppress the induction of IL-5 in response to IL-33.