Slowing down DNA translocation through solid-state nanopores by edge-field leakage

Ceming Wang; Sebastian Sensale; Zehao Pan; Satyajyoti Senapati; Hsueh-Chia Chang

doi:10.1038/s41467-020-20409-4

Nature Communications (Jan 2021)

Slowing down DNA translocation through solid-state nanopores by edge-field leakage

Ceming Wang,
Sebastian Sensale,
Zehao Pan,
Satyajyoti Senapati,
Hsueh-Chia Chang

Affiliations

Ceming Wang: Department of Chemical and Biomolecular Engineering, University of Notre Dame
Sebastian Sensale: Department of Aerospace and Mechanical Engineering, University of Notre Dame
Zehao Pan: Department of Chemical and Biomolecular Engineering, University of Notre Dame
Satyajyoti Senapati: Department of Chemical and Biomolecular Engineering, University of Notre Dame
Hsueh-Chia Chang: Department of Chemical and Biomolecular Engineering, University of Notre Dame

DOI: https://doi.org/10.1038/s41467-020-20409-4
Journal volume & issue: Vol. 12, no. 1
pp. 1 – 10

Abstract

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Solid-state nanopores can serve as single molecule sensors for DNA sequencing, but the current designs suffer from fast DNA translocation so low detectivity. Wang et al. slow down and control the translocation speed by 5 orders of magnitude using a leakage field generated at the nanopore tip.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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