The HAPSTR2 retrogene buffers stress signaling and resilience in mammals

David R. Amici; Harun Cingoz; Milad J. Alasady; Sammy Alhayek; Claire M. Phoumyvong; Nidhi Sahni; S. Stephen Yi; Marc L. Mendillo

doi:10.1038/s41467-022-35697-1

Nature Communications (Jan 2023)

The HAPSTR2 retrogene buffers stress signaling and resilience in mammals

David R. Amici,
Harun Cingoz,
Milad J. Alasady,
Sammy Alhayek,
Claire M. Phoumyvong,
Nidhi Sahni,
S. Stephen Yi,
Marc L. Mendillo

Affiliations

David R. Amici: Dept. of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine
Harun Cingoz: Dept. of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine
Milad J. Alasady: Dept. of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine
Sammy Alhayek: Dept. of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine
Claire M. Phoumyvong: Dept. of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine
Nidhi Sahni: Department of Epigenetics and Molecular Carcinogenesis, and Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center
S. Stephen Yi: Livestrong Cancer Institutes, Department of Oncology, and Department of Biomedical Engineering, The University of Texas at Austin
Marc L. Mendillo: Dept. of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine

DOI: https://doi.org/10.1038/s41467-022-35697-1
Journal volume & issue: Vol. 14, no. 1
pp. 1 – 12

Abstract

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The recently described protein HAPSTR1 governs cellular stress resilience. Here, the authors discover a mammalian HAPSTR1 paralog, called HAPSTR2, which formed via retro-transposition and operates to augment and buffer cellular stress signaling.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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