EVALUATION OF SINGLE PREOPERATIVE DOSE OF PREGABALIN IN TERMS OF POSTOPERATIVE PAIN AFTER LAPAROSCOPIC CHOLECYSTECTOMY

Abstract

Objective: Evaluation of single preoperative dose of pregabalin in terms of postoperative pain after laparoscopic cholecystectomy. Study Design: Randomized controlled trial (RCT). Place and Duration of Study: Study was conducted in Surgical Department of Military Hospital Rawalpindi over a period of one year fromJan 2013 to Dec 2013. Material and Methods: One hundred patients (50 in each group) were included in this study. They were divided into two groups. Group-A was given pregabalin and group-B was given placeboafter laparoscopic cholecystectomy. Results: Mean age was 38.2 ± 11.0 years in group A and 36.9 ± 11.7 years in group B. Regarding distribution of gender, 14 patients (28.0%) in group-A and 17 patients (34.0%) in group-B were males while 36 patients (72.0%) in group-A and 33 patients (66.0%) in group-B were females. Mean visual analogue score at 24 hours was 4.98 ± 1.87 and 6.58 ± 2.03 in group-A and B, respectively. The difference between two group was statistically significant (p<0.001). Analgesia was required in 17 patients (34.0%) in group-A and 37 patients of group-B. Conclusion: A single preoperative oral dose of pregabalin 150 mg was found very effective method for reducing postoperative pain in patients undergoing laparoscopic cholecystectomy.

Keywords

• laparoscopic cholecystectomy
• postoperative pain