Neuropsychiatric Disease and Treatment (Aug 2021)
Research Progress on PATJ and Underlying Mechanisms Associated with Functional Outcomes After Stroke
Abstract
Wen-Jie Wang,1 Tian-Jie Lyu,2,3 Zixiao Li1– 5 1Vascular Neurology, Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, 100070, People’s Republic of China; 2China National Clinical Research Center for Neurological Diseases, Beijing, 100070, People’s Republic of China; 3National Center for Healthcare Quality Management in Neurological Diseases, Beijing, 100070, People’s Republic of China; 4Chinese Institute for Brain Research, Beijing, 100070, People’s Republic of China; 5Research Unit of Artificial Intelligence in Cerebrovascular Disease, Chinese Academy of Medical Sciences, Beijing, 100070, People’s Republic of ChinaCorrespondence: Zixiao LiDepartment of Neurology, Beijing Tiantan Hospital, Capital Medical University, Chinese Institute for Brain Research, No. 119 West Road, Southern Fourth Ring Road, Beijing, 100070, People’s Republic of ChinaTel +86-1059978350Fax +86-1059973383Email [email protected]: Cell polarity is an intrinsic property of epithelial cells regulated by scaffold proteins. The CRB (crumbs) complex is known to play a predominant role in the dynamic cooperative network of polarity scaffold proteins. PATJ (PALS1-associated tight junction) is the core component in the CRB complex and has been highly conserved throughout evolution. PATJ is crucial to several important events in organisms’ survival, including embryonic development, cell polarity, and barrier establishment. A recent study shows that PATJ plays an important role in functional outcomes of stroke. In this article, we elaborate on the biological structure and physiological functions of PATJ and explore the underlying mechanisms of PATJ genetic polymorphism that are associated with poor functional outcomes in ischemic stroke.Keywords: PATJ, cell polarity, stroke
