ANTI-ACNE POTENCY OF WATER-SOLUBLE CHITOSAN PEEL-OFF GEL MASK AGAINST PROPIONIBACTERIUM ACNES

Abstract

Acne is a skin disease that one of the causes is bacteria. Acne can be treated with chemical antibiotics, but this medication could cause resistance, therefore it is required natural ingredients that can be used as an antibacterial against the Propionibacterium acnes bacteria. One of the natural ingredients that can be used is chitosan, but chitosan has a weakness that is only soluble in organic acid solvents so that its utilization is limited therefore it needs to be modified into water-soluble chitosan and to facilitate its application then the preparation of the peel-off mask. The purpose of this study is to know the effect of the addition of water-soluble chitosan with different concentrations of 150, 170 and 190 mg/ml and peel-off gel mask capability inhibits acne bacteria. The used method is an experimental method which includes antibacterial, time dries, pH, viscosities, organoleptics and irritation. The results showed that the best concentration peel-off gel mask in 190mg/ml, it was able to inhibit Propionibacterium acnes and were relatively strong. The test of drying time, pH and viscosities still meet the standard of the specified mask while organoleptic test of the color and smell best concentration is 150 mg/ml because it is considered similar to the control sample. Peel-off mask the soluble-chitosan is classified as safe because it does not cause erythema and edema after being tested on mouse skin.

Keywords

• peel-off gel mask
• water-soluble chitosan
• antibacterial
• irritation