Nature Communications (Feb 2022)

Modelling Chlamydia and HPV co-infection in patient-derived ectocervix organoids reveals distinct cellular reprogramming

  • Stefanie Koster,
  • Rajendra Kumar Gurumurthy,
  • Naveen Kumar,
  • Pon Ganish Prakash,
  • Jayabhuvaneshwari Dhanraj,
  • Sofia Bayer,
  • Hilmar Berger,
  • Shilpa Mary Kurian,
  • Marina Drabkina,
  • Hans-Joachim Mollenkopf,
  • Christian Goosmann,
  • Volker Brinkmann,
  • Zachary Nagel,
  • Mandy Mangler,
  • Thomas F. Meyer,
  • Cindrilla Chumduri

DOI
https://doi.org/10.1038/s41467-022-28569-1
Journal volume & issue
Vol. 13, no. 1
pp. 1 – 15

Abstract

Read online

Here, Koster et al., model human papillomavirus and Chlamydia coinfection dynamics in patient-derived ectocervical organoids, and characterize the effects of multiple infections in the cellular microenvironment, potentially contributing to neoplasia.