Nature Communications (Jul 2021)
Plasmodium falciparum transcription in different clinical presentations of malaria associates with circulation time of infected erythrocytes
- Richard Thomson-Luque,
- Lasse Votborg-Novél,
- Wanangwa Ndovie,
- Carolina M. Andrade,
- Moussa Niangaly,
- Charalampos Attipa,
- Nathalia F. Lima,
- Drissa Coulibaly,
- Didier Doumtabe,
- Bouréima Guindo,
- Bourama Tangara,
- Fayçal Maiga,
- Abdoulaye Kassoum Kone,
- Karim Traore,
- Kassoum Kayentao,
- Aissata Ongoiba,
- Safiatou Doumbo,
- Mahamadou A. Thera,
- Boubacar Traoré,
- Karl Seydel,
- Nuno S. Osório,
- Silvia Portugal
Affiliations
- Richard Thomson-Luque
- Centre of Infectious Diseases, Parasitology, Heidelberg University Hospital
- Lasse Votborg-Novél
- Centre of Infectious Diseases, Parasitology, Heidelberg University Hospital
- Wanangwa Ndovie
- Malawi-Liverpool-Wellcome Trust Clinical Research Programme
- Carolina M. Andrade
- Centre of Infectious Diseases, Parasitology, Heidelberg University Hospital
- Moussa Niangaly
- Max Planck Institute for Infection Biology
- Charalampos Attipa
- Malawi-Liverpool-Wellcome Trust Clinical Research Programme
- Nathalia F. Lima
- Centre of Infectious Diseases, Parasitology, Heidelberg University Hospital
- Drissa Coulibaly
- Mali International Center of Excellence in Research, Malaria Research and Training Centre (MRTC), University of Sciences Techniques and Technologies of Bamako
- Didier Doumtabe
- Mali International Center of Excellence in Research, Malaria Research and Training Centre (MRTC), University of Sciences Techniques and Technologies of Bamako
- Bouréima Guindo
- Mali International Center of Excellence in Research, Malaria Research and Training Centre (MRTC), University of Sciences Techniques and Technologies of Bamako
- Bourama Tangara
- Mali International Center of Excellence in Research, Malaria Research and Training Centre (MRTC), University of Sciences Techniques and Technologies of Bamako
- Fayçal Maiga
- Mali International Center of Excellence in Research, Malaria Research and Training Centre (MRTC), University of Sciences Techniques and Technologies of Bamako
- Abdoulaye Kassoum Kone
- Mali International Center of Excellence in Research, Malaria Research and Training Centre (MRTC), University of Sciences Techniques and Technologies of Bamako
- Karim Traore
- Mali International Center of Excellence in Research, Malaria Research and Training Centre (MRTC), University of Sciences Techniques and Technologies of Bamako
- Kassoum Kayentao
- Mali International Center of Excellence in Research, Malaria Research and Training Centre (MRTC), University of Sciences Techniques and Technologies of Bamako
- Aissata Ongoiba
- Mali International Center of Excellence in Research, Malaria Research and Training Centre (MRTC), University of Sciences Techniques and Technologies of Bamako
- Safiatou Doumbo
- Mali International Center of Excellence in Research, Malaria Research and Training Centre (MRTC), University of Sciences Techniques and Technologies of Bamako
- Mahamadou A. Thera
- Mali International Center of Excellence in Research, Malaria Research and Training Centre (MRTC), University of Sciences Techniques and Technologies of Bamako
- Boubacar Traoré
- Mali International Center of Excellence in Research, Malaria Research and Training Centre (MRTC), University of Sciences Techniques and Technologies of Bamako
- Karl Seydel
- Blantyre Malaria Project, University of Malawi College of Medicine
- Nuno S. Osório
- Life and Health Sciences Research Institute (ICVS), School of Medicine, University of Minho
- Silvia Portugal
- Centre of Infectious Diseases, Parasitology, Heidelberg University Hospital
- DOI
- https://doi.org/10.1038/s41467-021-25062-z
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
To understand malaria symptoms, several studies investigate association between parasite’s transcriptome and disease severity. Here, Thomson-Luque et al. reanalyze available transcriptomic data of P. falciparum and find that longer circulation of infected erythrocytes without sequestering to endothelial cells associates with decreasing parasitaemia and less severe disease.
