Nature Communications (Mar 2021)
RALYL increases hepatocellular carcinoma stemness by sustaining the mRNA stability of TGF-β2
- Xia Wang,
- Jin Wang,
- Yu-Man Tsui,
- Chaoran Shi,
- Ying Wang,
- Xin Zhang,
- Qian Yan,
- Miao Chen,
- Chen Jiang,
- Yun-Fei Yuan,
- Chun-Ming Wong,
- Ming Liu,
- Zeng-yu Feng,
- Honglin Chen,
- Irene Oi Lin Ng,
- Lingxi Jiang,
- Xin-Yuan Guan
Affiliations
- Xia Wang
- Department of Clinical Oncology, The University of Hong Kong
- Jin Wang
- School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Yu-Man Tsui
- State key Laboratory of Liver Research, The University of Hong Kong
- Chaoran Shi
- Department of Clinical Oncology, The University of Hong Kong
- Ying Wang
- Department of Clinical Oncology, The University of Hong Kong
- Xin Zhang
- State key Laboratory of Liver Research, The University of Hong Kong
- Qian Yan
- Department of Clinical Oncology, The University of Hong Kong
- Miao Chen
- Department of Clinical Oncology, The University of Hong Kong
- Chen Jiang
- Department of Clinical Oncology, The University of Hong Kong
- Yun-Fei Yuan
- State Key Laboratory of Oncology in Southern China, Sun Yat-Sen University Cancer Center
- Chun-Ming Wong
- State key Laboratory of Liver Research, The University of Hong Kong
- Ming Liu
- Department of Clinical Oncology, The University of Hong Kong
- Zeng-yu Feng
- Department of General Surgery, Ruijin Hospital, Shanghai JiaoTong University School of Medicine
- Honglin Chen
- Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong
- Irene Oi Lin Ng
- State key Laboratory of Liver Research, The University of Hong Kong
- Lingxi Jiang
- State key Laboratory of Liver Research, The University of Hong Kong
- Xin-Yuan Guan
- Department of Clinical Oncology, The University of Hong Kong
- DOI
- https://doi.org/10.1038/s41467-021-21828-7
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 14
Abstract
RALYL is a liver progenitor cell-specific gene but its role in hepatocellular carcinoma (HCC) remains unknown. Here, the authors demonstrate that RALYL regulates HCC stemness through upregulation of TGF-β2 mRNA stability by decreasing N6-methyladenosine modification.
