Emerging Infectious Diseases (Dec 2022)

Omicron BA.5 Neutralization among Vaccine-Boosted Persons with Prior Omicron BA.1/BA.2 Infections

  • Rune M. Pedersen,
  • Line L. Bang,
  • Ditte S. Tornby,
  • Lone W. Madsen,
  • Dorte K. Holm,
  • Thomas V. Sydenham,
  • Isik S. Johansen,
  • Thøger G. Jensen,
  • Ulrik S. Justesen,
  • Thomas E. Andersen

DOI
https://doi.org/10.3201/eid2812.221304
Journal volume & issue
Vol. 28, no. 12
pp. 2575 – 2577

Abstract

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Worldwide, millions of persons have received multiple COVID-19 vaccinations and subsequently recovered from SARS-CoV-2 Omicron breakthrough infections. In 2 small, matched cohorts (n = 12, n = 24) in Denmark, we found Omicron BA.1/BA.2 breakthrough infection after 3-dose BNT162b2 vaccination provided improved Omicron BA.5 neutralization over 3-dose vaccination alone.

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