Primary Cutaneous Anaplastic Large Cell Lymphoma of the Oral Cavity Successfully Treated with Brentuximab Vedotin

Federico Meconi; Roberto Secchi; Raffaele Palmieri; Sara Vaccarini; Vito Mario Rapisarda; Laura Giannì; Fabiana Esposito; Ida Provenzano; Daniela Nasso; Livio Pupo; Maria Cantonetti

doi:10.1155/2019/9651207

Case Reports in Hematology (Jan 2019)

Primary Cutaneous Anaplastic Large Cell Lymphoma of the Oral Cavity Successfully Treated with Brentuximab Vedotin

Federico Meconi,
Roberto Secchi,
Raffaele Palmieri,
Sara Vaccarini,
Vito Mario Rapisarda,
Laura Giannì,
Fabiana Esposito,
Ida Provenzano,
Daniela Nasso,
Livio Pupo,
Maria Cantonetti

Affiliations

Federico Meconi: Department of Biomedicine and Prevention, Haematology Division, University of Tor Vergata, Viale Oxford 81, Rome, Italy
Roberto Secchi: Department of Biomedicine and Prevention, Haematology Division, University of Tor Vergata, Viale Oxford 81, Rome, Italy
Raffaele Palmieri: Department of Biomedicine and Prevention, Haematology Division, University of Tor Vergata, Viale Oxford 81, Rome, Italy
Sara Vaccarini: Department of Biomedicine and Prevention, Haematology Division, University of Tor Vergata, Viale Oxford 81, Rome, Italy
Vito Mario Rapisarda: Department of Biomedicine and Prevention, Haematology Division, University of Tor Vergata, Viale Oxford 81, Rome, Italy
Laura Giannì: Department of Biomedicine and Prevention, Haematology Division, University of Tor Vergata, Viale Oxford 81, Rome, Italy
Fabiana Esposito: Department of Biomedicine and Prevention, Haematology Division, University of Tor Vergata, Viale Oxford 81, Rome, Italy
Ida Provenzano: Department of Biomedicine and Prevention, Haematology Division, University of Tor Vergata, Viale Oxford 81, Rome, Italy
Daniela Nasso: Department of Biomedicine and Prevention, Haematology Division, University of Tor Vergata, Viale Oxford 81, Rome, Italy
Livio Pupo: Department of Biomedicine and Prevention, Haematology Division, University of Tor Vergata, Viale Oxford 81, Rome, Italy
Maria Cantonetti: Department of Biomedicine and Prevention, Haematology Division, University of Tor Vergata, Viale Oxford 81, Rome, Italy

DOI: https://doi.org/10.1155/2019/9651207
Journal volume & issue: Vol. 2019

Abstract

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Primary cutaneous anaplastic large cell lymphoma is a CD-30 positive lymphoproliferative disorder with good prognosis, usually treated with radiation therapy and surgery. Head, neck, and extremities are the most frequently involved sites. In this paper, we describe an unusual case of oral localization, recurring after skin-involving radiotherapy, successfully treated with sixteen cycles of brentuximab vedotin. This could be a more effective approach with a less detrimental toll for treating these rare disorders.

Published in Case Reports in Hematology

ISSN: 2090-6560 (Print); 2090-6579 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the blood and blood-forming organs
Website: https://onlinelibrary.wiley.com/journal/3191

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