Wellcome Open Research (Jan 2023)
Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples [version 1; peer review: 2 approved]
- Mohamed Hassan Abdelraheem,
- Sonia Goncalves,
- Lemu Golassa,
- Tim Anderson,
- Desmond Omane Acheampong,
- Enoch Aninagyei,
- Ifeyinwa Aniebo,
- Patrick O Ansah,
- Felix Ansah,
- Gordon A Awandare,
- Paulo Arnaldo,
- Maciej F Boni,
- Gwladys I Bertin,
- Peter C Bull,
- Marielle Bouyou-Akotet,
- Keobouphaphone Chindavongsa,
- Edwin Kamau,
- Huch Cheah,
- Claire Kamaliddin,
- Vladimir Corredor,
- David J Conway,
- Nicholas Day,
- Abibatou Konaté,
- Erin Courtier,
- Theerarat Kochakarn,
- Arjen Dondorp,
- Abdoulaye Djimde,
- Diego F Echeverry,
- Seydou Doumbia,
- Mara Lawniczak,
- Pharath Lim,
- Sonia Maria Mauricio Enosse,
- Oumou Maïga-Ascofaré,
- Thomas G Egwang,
- Aung Myint Thu,
- Mark Fleharty,
- Jutta Marfurt,
- Caterina A Fanello,
- Mark Fukuda,
- Victor Mobegi,
- Matthew Forbes,
- Sara Anne Healy,
- G L Abby Harrison,
- Anastasia Hernandez-Koutoucheva,
- Jason A Hendry,
- Ivo Mueller,
- Francis Hombhanje,
- Harald Noedl,
- Catherine A Hill,
- Thuy-Nhien Nguyen,
- Mazza Hussein,
- Amanda Hott,
- Rintis Noviyanti,
- Scott A Jackson,
- Abraham Oduro,
- Deus Ishengoma,
- Harold Ocholla,
- Julia Jeans,
- Jean-Bosco Ouedraogo,
- Chris G Jacob,
- Drissa S Konate,
- Jon Keatley,
- Francois Nosten,
- Kolapo Oyebola,
- Myat P Kyaw,
- Aminatou Kone,
- Norbert Peshu,
- Samuel K Lee,
- Dennis Kyle,
- Kovana M Loua,
- Milijaona Randrianarivelojosia,
- Martha Lemnge,
- Sasithon Pukrittayakamee,
- Richard James Maude,
- Pascal Ringwald,
- Celine I Mandara,
- Abdelrahim Osman Mohamed,
- Toshihiro Mita,
- Jaqui Montgomery,
- Julian C Rayner,
- David Saunders,
- Olugbenga A Mokuolu,
- Lastenia Ruiz,
- Kathryn Murie,
- Peter Siba,
- Collins Misita Morang’a,
- Alex Shayo,
- Tuyen Nguyen Thi Kim,
- Thang Ngo Duc,
- Vincent Ntui-Njock Ntui,
- Colin Sutherland,
- Hong Nguyen Van,
- Xin-zhuan Su,
- Marie A Onyamboko,
- Livingstone Tavul,
- Irene Omedo,
- Richard Pearson,
- Antoinette Tshefu,
- Wellington Aghoghovwia Oyibo,
- Vandana Thathy,
- Chris Drakeley,
- Huynh Hong Quang,
- Joseph Vinetz,
- Christopher V Plowe,
- Federica Verra,
- Eduard Rovira-Vallbona,
- Jason Wendler,
- Anna Rosanas-Urgell,
- Teun Bousema,
- Thuy Nguyen,
- Mahamadou S. Sissoko,
- Valentin Ruano-Rubio,
- Alexis Nzila,
- Shannon Takala-Harrison,
- Christen Smith,
- William Yavo,
- Ngo Viet Thanh,
- Arthur Talman,
- Georgia Whitton,
- Mahamoudou Toure,
- Rob W van der Pluijm,
- Sarah Auburn,
- Antoine Claessens,
- Mahamadou Diakite,
- Kesinee Chotivanich,
- Mehul Dhorda,
- Olivo Miotto,
- Mallika Imwong,
- Mayfong Mayxay,
- Alfred Amambua-Ngwa,
- Philip Bejon,
- Elizabeth Ashley,
- Alyssa Barry,
- Rick M. Fairhurst,
- Ye Htut,
- Tran Tinh Hien,
- Kimberly J Johnson,
- Dominic P Kwiatkowski,
- Umberto D'Alessandro,
- Chanthap Lon,
- Paul N Newton,
- Aung P Phyo,
- Ric N Price,
- Victoria J Simpson,
- Kevin Marsh,
- Nicholas J White,
- Thomas E Wellems,
- Lynette Isabella Ochola-Oyier,
- Mozam Ali,
- Ambroise Ahouidi,
- Jacob Almagro-Garcia,
- Ben Andagalu,
- Lucas Amenga-Etego,
- Voahangy Andrianaranjaka,
- Tobias Apinjoh,
- Vito Baraka,
- Hampate Ba,
- Steffen Borrmann,
- Oralee Branch,
- Thanat Chookajorn,
- Souleymane Dama,
- Chanaki Amaratunga,
- Alister Craig,
- Brigitte Denis,
- Eleanor Drury,
- Christiane Dolecek,
- Patrick Duffy,
- Berhanu Erko,
- Abdul Faiz,
- Muzamil Mahdi Abdel Hamid,
- Anita Ghansah,
- Dionicia Gamboa
Affiliations
- Mohamed Hassan Abdelraheem
- Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
- Sonia Goncalves
- Wellcome Sanger Institute, Hinxton, UK
- Lemu Golassa
- ORCiD
- Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia
- Tim Anderson
- ORCiD
- Texas Biomedical Research Institute, San Antonio, USA
- Desmond Omane Acheampong
- Department of Biomedical Sciences, School of Allied Health Sciences, University of Cape Coast, Cape Coast, Ghana
- Enoch Aninagyei
- Department of Biomedical Sciences, School of Basic and Biomedical Sciences, University of Health & Allied Sciences, Ho, Ghana
- Ifeyinwa Aniebo
- Health Strategy and Delivery Foundation, Lagos, Nigeria
- Patrick O Ansah
- ORCiD
- Navrongo Health Research Centre, Ghana Health Service, Navrongo, Ghana
- Felix Ansah
- West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon, Ghana
- Gordon A Awandare
- West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon, Ghana
- Paulo Arnaldo
- Instituto Nacional de Saúde (INS), Maputo, Mozambique
- Maciej F Boni
- ORCiD
- Nuffield Department of Medicine, University of Oxford, UK
- Gwladys I Bertin
- ORCiD
- Institute of Research for Development (IRD), Paris, France
- Peter C Bull
- KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
- Marielle Bouyou-Akotet
- Department of Parasitology-Mycology, Université des Sciences de la Santé, Libreville, Gabon
- Keobouphaphone Chindavongsa
- Center of Malariology, Parasitology and Entomology (CMPE), Vientiane, Lao People's Democratic Republic
- Edwin Kamau
- ORCiD
- U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, MD, USA
- Huch Cheah
- National Center for Parasitology, Entomology and Malaria Control, Phnom Penh, Cambodia
- Claire Kamaliddin
- ORCiD
- Institute of Research for Development (IRD), Paris, France
- Vladimir Corredor
- National University of Colombia, Bogota, Colombia
- David J Conway
- ORCiD
- London School of Hygiene and Tropical Medicine, London, UK
- Nicholas Day
- ORCiD
- Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand
- Abibatou Konaté
- University Félix Houphouët-Boigny, Abidjan, Cote d'Ivoire
- Erin Courtier
- Wellcome Sanger Institute, Hinxton, UK
- Theerarat Kochakarn
- Mahidol University, Bangkok, Thailand
- Arjen Dondorp
- ORCiD
- Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand
- Abdoulaye Djimde
- ORCiD
- Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali
- Diego F Echeverry
- ORCiD
- Departamento de Microbiología, Universidad del Valle, Cali, Colombia
- Seydou Doumbia
- Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali
- Mara Lawniczak
- ORCiD
- Wellcome Sanger Institute, Hinxton, UK
- Pharath Lim
- National Institute of Allergy and Infectious Diseases (NIAID), NIH, Maryland, USA
- Sonia Maria Mauricio Enosse
- Instituto Nacional de Saúde (INS), Maputo, Mozambique
- Oumou Maïga-Ascofaré
- Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali
- Thomas G Egwang
- Biotech Laboratories, Kampala, Uganda
- Aung Myint Thu
- Shoklo Malaria Research Unit, Mahidol-Oxford Tropical Medicine Research Unit, Faculty of Tropical Medicine, Mahidol University, Mae Sot, Thailand
- Mark Fleharty
- Broad Institute of Harvard and MIT and Harvard, Cambridge, MA, USA
- Jutta Marfurt
- Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
- Caterina A Fanello
- ORCiD
- Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand
- Mark Fukuda
- Department of Immunology and Medicine, US Army Medical Component, Armed Forces Research Institute of Medical Sciences (USAMC-AFRIMS), Bangkok, Thailand
- Victor Mobegi
- ORCiD
- Department of Biochemistry and Centre for Biotechnology and Bioinformatics, University of Nairobi, Nairobi, Kenya
- Matthew Forbes
- Wellcome Sanger Institute, Hinxton, UK
- Sara Anne Healy
- ORCiD
- National Institute of Allergy and Infectious Diseases (NIAID), NIH, Maryland, USA
- G L Abby Harrison
- Walter and Eliza Hall Institute, Melbourne, Australia
- Anastasia Hernandez-Koutoucheva
- Wellcome Sanger Institute, Hinxton, UK
- Jason A Hendry
- Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK
- Ivo Mueller
- Walter and Eliza Hall Institute, Melbourne, Australia
- Francis Hombhanje
- Centre for Health Research & Diagnostics, Divine Word University, Madang, Papua New Guinea
- Harald Noedl
- MARIB - Malaria Research Initiative Bandarban, Bandarban, Bangladesh
- Catherine A Hill
- Department of Entomology, Purdue University, West Lafayette, USA
- Thuy-Nhien Nguyen
- ORCiD
- Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK
- Mazza Hussein
- Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
- Amanda Hott
- University of South Florida, Tampa, USA
- Rintis Noviyanti
- Eijkman Institute for Molecular Biology, Jakarta, Indonesia
- Scott A Jackson
- ORCiD
- Center for Applied Genetic Technologies, University of Georgia, Athens, GA, USA
- Abraham Oduro
- ORCiD
- Navrongo Health Research Centre, Ghana Health Service, Navrongo, Ghana
- Deus Ishengoma
- ORCiD
- National Institute for Medical Research (NIMR), Dar es Salaam, Tanzania
- Harold Ocholla
- KEMRI Centres for Disease Control and Prevention (CDC) Research Program, Kisumu, Kenya
- Julia Jeans
- Wellcome Sanger Institute, Hinxton, UK
- Jean-Bosco Ouedraogo
- ORCiD
- Institut de Recherche en Sciences de la Santé, Ouagadougou, Burkina Faso
- Chris G Jacob
- Wellcome Sanger Institute, Hinxton, UK
- Drissa S Konate
- ORCiD
- Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali
- Jon Keatley
- Wellcome Sanger Institute, Hinxton, UK
- Francois Nosten
- ORCiD
- Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK
- Kolapo Oyebola
- ORCiD
- Nigerian Institute of Medical Research, Lagos, Nigeria
- Myat P Kyaw
- Myanmar Oxford Clinical Research Unit, University of Oxford, Yangon, Myanmar
- Aminatou Kone
- Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali
- Norbert Peshu
- KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
- Samuel K Lee
- Broad Institute of Harvard and MIT and Harvard, Cambridge, MA, USA
- Dennis Kyle
- ORCiD
- University of South Florida, Tampa, USA
- Kovana M Loua
- ORCiD
- University Gamal Abdel Nasser of Conakry, Conakry, Guinea
- Milijaona Randrianarivelojosia
- Institut Pasteur de Madagascar, Antananarivo, Madagascar
- Martha Lemnge
- National Institute for Medical Research (NIMR), Dar es Salaam, Tanzania
- Sasithon Pukrittayakamee
- Mahidol University, Bangkok, Thailand
- Richard James Maude
- Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand
- Pascal Ringwald
- World Health Organization (WHO), Geneva, Switzerland
- Celine I Mandara
- National Institute for Medical Research (NIMR), Dar es Salaam, Tanzania
- Abdelrahim Osman Mohamed
- Faculty of Medicine, University of Khartoum, Khartoum, Sudan
- Toshihiro Mita
- ORCiD
- Juntendo University, Tokyo, Japan
- Jaqui Montgomery
- Malawi-Liverpool-Wellcome Trust Clinical Research Program, Blantyre, Malawi
- Julian C Rayner
- ORCiD
- Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK
- David Saunders
- Department of Medicine, Uniformed Services University, Bethesda, MD, USA
- Olugbenga A Mokuolu
- Department of Paediatrics and Child Health, University of Ilorin, Ilorin, Nigeria
- Lastenia Ruiz
- Universidad Nacional de la Amazonia Peruana, Iquitos, Peru
- Kathryn Murie
- Wellcome Sanger Institute, Hinxton, UK
- Peter Siba
- Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
- Collins Misita Morang’a
- ORCiD
- West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon, Ghana
- Alex Shayo
- ORCiD
- Nelson Mandela Institute of Science and Technology, Arusha, Tanzania
- Tuyen Nguyen Thi Kim
- Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Vietnam
- Thang Ngo Duc
- National Institute of Malariology, Parasitology and Entomology (NIMPE), Hanoi, Vietnam
- Vincent Ntui-Njock Ntui
- ORCiD
- University of Buea, Buea, Cameroon
- Colin Sutherland
- London School of Hygiene and Tropical Medicine, London, UK
- Hong Nguyen Van
- National Institute of Malariology, Parasitology and Entomology (NIMPE), Hanoi, Vietnam
- Xin-zhuan Su
- ORCiD
- National Institute of Allergy and Infectious Diseases (NIAID), NIH, Maryland, USA
- Marie A Onyamboko
- ORCiD
- Kinshasa School of Public Health, University of Kinshasa, Kinshasa, Congo, Democratic Republic
- Livingstone Tavul
- Papua New Guinea Institute of Medical Research, Goroka, Papua New Guinea
- Irene Omedo
- Wellcome Sanger Institute, Hinxton, UK
- Richard Pearson
- ORCiD
- Wellcome Sanger Institute, Hinxton, UK
- Antoinette Tshefu
- University of Kinshasa, Kinsasha, Congo, Democratic Republic
- Wellington Aghoghovwia Oyibo
- College of Medicine, University of Lagos, Lagos, Nigeria
- Vandana Thathy
- KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
- Chris Drakeley
- ORCiD
- London School of Hygiene and Tropical Medicine, London, UK
- Huynh Hong Quang
- Institute of Malariology, Parasitology, and Entomology (IMPE) Quy Nhon, Ministry of Health, Quy Nhon, Vietnam
- Joseph Vinetz
- ORCiD
- Laboratorio ICEMR-Amazonia, Laboratorios de Investigacion y Desarrollo, Facultad de Ciencias y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru
- Christopher V Plowe
- University of Maryland School of Medicine, Maryland, USA
- Federica Verra
- Sapienza University of Rome, Rome, Italy
- Eduard Rovira-Vallbona
- Institute of Tropical Medicine Antwerp, Antwerp, Belgium
- Jason Wendler
- National Institute of Allergy and Infectious Diseases (NIAID), NIH, Maryland, USA
- Anna Rosanas-Urgell
- ORCiD
- Institute of Tropical Medicine Antwerp, Antwerp, Belgium
- Teun Bousema
- ORCiD
- London School of Hygiene and Tropical Medicine, London, UK
- Thuy Nguyen
- Wellcome Sanger Institute, Hinxton, UK
- Mahamadou S. Sissoko
- Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali
- Valentin Ruano-Rubio
- Broad Institute of Harvard and MIT and Harvard, Cambridge, MA, USA
- Alexis Nzila
- King Fahid University of Petroleum and Minerals (KFUMP), Dhahran, Saudi Arabia
- Shannon Takala-Harrison
- Center for Vaccine Development and Global Health, University of Maryland, School of Medicine, Baltimore, MD, USA
- Christen Smith
- Wellcome Sanger Institute, Hinxton, UK
- William Yavo
- University Félix Houphouët-Boigny, Abidjan, Cote d'Ivoire
- Ngo Viet Thanh
- Oxford University Clinical Research Unit (OUCRU), Ho Chi Minh City, Vietnam
- Arthur Talman
- MIVEGEC, Université de Montpellier, IRD, CNRS, Montpellier, France
- Georgia Whitton
- Wellcome Sanger Institute, Hinxton, UK
- Mahamoudou Toure
- Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali
- Rob W van der Pluijm
- Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand
- Sarah Auburn
- Menzies School of Health Research, Charles Darwin University, Darwin, Northern Territory, Australia
- Antoine Claessens
- ORCiD
- Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul, The Gambia
- Mahamadou Diakite
- ORCiD
- Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali
- Kesinee Chotivanich
- Mahidol University, Bangkok, Thailand
- Mehul Dhorda
- Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand
- Olivo Miotto
- ORCiD
- Wellcome Sanger Institute, Hinxton, UK
- Mallika Imwong
- Mahidol University, Bangkok, Thailand
- Mayfong Mayxay
- ORCiD
- Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK
- Alfred Amambua-Ngwa
- Wellcome Sanger Institute, Hinxton, UK
- Philip Bejon
- ORCiD
- KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
- Elizabeth Ashley
- ORCiD
- Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand
- Alyssa Barry
- Walter and Eliza Hall Institute, Melbourne, Australia
- Rick M. Fairhurst
- National Institutes of Health (NIH), Maryland, USA
- Ye Htut
- Department of Medical Research, Yangon, Myanmar
- Tran Tinh Hien
- Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK
- Kimberly J Johnson
- Wellcome Sanger Institute, Hinxton, UK
- Dominic P Kwiatkowski
- ORCiD
- Wellcome Sanger Institute, Hinxton, UK
- Umberto D'Alessandro
- ORCiD
- Medical Research Council Unit The Gambia at the London School of Hygiene and Tropical Medicine, Banjul, The Gambia
- Chanthap Lon
- National Institute of Allergy and Infectious Diseases, Phnom Penh, Cambodia
- Paul N Newton
- Centre for Tropical Medicine and Global Health, University of Oxford, Oxford, UK
- Aung P Phyo
- ORCiD
- Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand
- Ric N Price
- ORCiD
- Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand
- Victoria J Simpson
- Wellcome Sanger Institute, Hinxton, UK
- Kevin Marsh
- ORCiD
- Nuffield Department of Medicine, University of Oxford, UK
- Nicholas J White
- Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand
- Thomas E Wellems
- ORCiD
- National Institute of Allergy and Infectious Diseases (NIAID), NIH, Maryland, USA
- Lynette Isabella Ochola-Oyier
- KEMRI Wellcome Trust Research Programme, Kilifi, Kenya
- Mozam Ali
- Wellcome Sanger Institute, Hinxton, UK
- Ambroise Ahouidi
- Health Research Epidemiological Surveillance and Training Institute (IRESSEF), Université Cheikh Anta Diop, Dakar, Senegal
- Jacob Almagro-Garcia
- Wellcome Sanger Institute, Hinxton, UK
- Ben Andagalu
- United States Army Medical Research Directorate-Africa, Kenya Medical Research Institute/Walter Reed Project, Kisumu, Kenya
- Lucas Amenga-Etego
- ORCiD
- West African Centre for Cell Biology of Infectious Pathogens (WACCBIP), University of Ghana, Legon, Ghana
- Voahangy Andrianaranjaka
- Université d'Antananarivo, Antananarivo, Madagascar
- Tobias Apinjoh
- University of Buea, Buea, Cameroon
- Vito Baraka
- ORCiD
- National Institute for Medical Research (NIMR), Dar es Salaam, Tanzania
- Hampate Ba
- ORCiD
- Institut National de Recherche en Santé Publique, Nouakchott, Mauritania
- Steffen Borrmann
- Institute for Tropical Medicine, University of Tübingen, Tübingen, Germany
- Oralee Branch
- NYU School of Medicine Langone Medical Center, New York, USA
- Thanat Chookajorn
- ORCiD
- Mahidol University, Bangkok, Thailand
- Souleymane Dama
- Malaria Research and Training Centre, University of Science, Techniques and Technologies of Bamako, Bamako, Mali
- Chanaki Amaratunga
- National Institute of Allergy and Infectious Diseases (NIAID), NIH, Maryland, USA
- Alister Craig
- ORCiD
- Liverpool School of Tropical Medicine, Liverpool, UK
- Brigitte Denis
- Malawi-Liverpool-Wellcome Trust Clinical Research Program, Blantyre, Malawi
- Eleanor Drury
- Wellcome Sanger Institute, Hinxton, UK
- Christiane Dolecek
- Nuffield Department of Medicine, University of Oxford, UK
- Patrick Duffy
- National Institute of Allergy and Infectious Diseases (NIAID), NIH, Maryland, USA
- Berhanu Erko
- ORCiD
- Aklilu Lemma Institute of Pathobiology, Addis Ababa University, Addis Ababa, Ethiopia
- Abdul Faiz
- ORCiD
- Dev Care Foundation, Dhaka, Bangladesh
- Muzamil Mahdi Abdel Hamid
- Institute of Endemic Diseases, University of Khartoum, Khartoum, Sudan
- Anita Ghansah
- Nogouchi Memorial Institute for Medical Research, Legon-Accra, Ghana
- Dionicia Gamboa
- ORCiD
- Laboratorio ICEMR-Amazonia, Laboratorios de Investigacion y Desarrollo, Facultad de Ciencias y Filosofia, Universidad Peruana Cayetano Heredia, Lima, Peru
- Journal volume & issue
-
Vol. 8
Abstract
We describe the MalariaGEN Pf7 data resource, the seventh release of Plasmodium falciparum genome variation data from the MalariaGEN network. It comprises over 20,000 samples from 82 partner studies in 33 countries, including several malaria endemic regions that were previously underrepresented. For the first time we include dried blood spot samples that were sequenced after selective whole genome amplification, necessitating new methods to genotype copy number variations. We identify a large number of newly emerging crt mutations in parts of Southeast Asia, and show examples of heterogeneities in patterns of drug resistance within Africa and within the Indian subcontinent. We describe the profile of variations in the C-terminal of the csp gene and relate this to the sequence used in the RTS,S and R21 malaria vaccines. Pf7 provides high-quality data on genotype calls for 6 million SNPs and short indels, analysis of large deletions that cause failure of rapid diagnostic tests, and systematic characterisation of six major drug resistance loci, all of which can be freely downloaded from the MalariaGEN website.
