Beilstein Journal of Organic Chemistry (Apr 2022)

Sesquiterpenes from the soil-derived fungus Trichoderma citrinoviride PSU-SPSF346

  • Wiriya Yaosanit,
  • Vatcharin Rukachaisirikul,
  • Souwalak Phongpaichit,
  • Sita Preedanon,
  • Jariya Sakayaroj

DOI
https://doi.org/10.3762/bjoc.18.50
Journal volume & issue
Vol. 18, no. 1
pp. 479 – 485

Abstract

Read online

Two new sesquiterpenes, trichocitrinovirenes A (1) and B (2), and five known compounds including four structurally related sesquiterpenes and one γ-lactone were isolated from the soil-derived fungus Trichoderma citrinoviride PSU-SPSF346. The structures were identified by analysis of their spectroscopic data. The relative configuration was assigned based on NOEDIFF data. The absolute configuration of compound 1 was established according to specific rotations and ECD data while that of compound 2 was proposed based on biosynthetic considerations. Compound 2 possesses a rare bicyclic sesquiterpene skeleton. The antimicrobial and cytotoxic activities of the isolated compounds were evaluated.

Keywords