Nature Communications (Dec 2017)
Structural basis for genome wide recognition of 5-bp GC motifs by SMAD transcription factors
Abstract
Smad transcription factors are part of the TGF-β signal transduction pathways and are recruited to the genome by cell lineage-defining factors. Here, the authors identify specific Smad binding GC-rich motifs and provide structural information showing Smad3 and Smad4 bound to these motifs.