Altered Visual Plasticity in Morbidly Obese Subjects
Claudia Lunghi,
Giuseppe Daniele,
Paola Binda,
Angela Dardano,
Giovanni Ceccarini,
Ferruccio Santini,
Stefano Del Prato,
Maria Concetta Morrone
Affiliations
Claudia Lunghi
Laboratoire des Systèmes Perceptifs, Département d’études Cognitives, École Normale Supérieure, PSL University, CNRS, 75005 Paris, France
Giuseppe Daniele
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Paola Binda
Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Via San Zeno 31, 56123 Pisa, Italy
Angela Dardano
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Giovanni Ceccarini
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Ferruccio Santini
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Stefano Del Prato
Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy
Maria Concetta Morrone
Department of Translational Research on New Technologies in Medicine and Surgery, University of Pisa, Via San Zeno 31, 56123 Pisa, Italy; IRCCS Stella Maris, Calambrone, Pisa, Italy; Corresponding author
Summary: Growing evidence indicates a close link between energy metabolism and neural plasticity as obesity is associated with alterations of cognitive functions, memory, and hippocampal neurogenesis. However, it is still unknown whether obesity can affect low-level sensory plasticity. Here we investigated this issue by probing early visual plasticity induced by short-term (2 h) monocular deprivation in a group of adult volunteers with a wide range of Body Mass Index (BMI), from normal weight to morbid obesity. We found that the effect of monocular deprivation decreased with increasing BMI, and morbidly obese subjects (BMI>40) failed to show the homeostatic plasticity effect seen in normal-weight participants. In addition, morbidly obese subjects exhibited altered binocular rivalry dynamics compared with normal-weight observers. These results show for the first time that the impact of obesity observed at the neural and cognitive level extends to basic sensory processing and plasticity. : Physiological State; Biological Sciences; Neuroscience; Sensory Neuroscience Subject Areas: Physiological State, Biological Sciences, Neuroscience, Sensory Neuroscience
