Sequence Tolerance of a Single-Domain Antibody with a High Thermal Stability: Comparison of Computational and Experimental Fitness Profiles

• Mark A. Olson,
• Patricia M. Legler,
• Daniel Zabetakis,
• Kendrick B. Turner,
• George P. Anderson,
• Ellen R. Goldman

Affiliations

Mark A. Olson

Systems and Structural Biology Division, USAMRIID, Frederick, Maryland, United States

Patricia M. Legler

Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, District of Columbia, United States

Daniel Zabetakis

Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, District of Columbia, United States

Kendrick B. Turner

Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, District of Columbia, United States

George P. Anderson

Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, District of Columbia, United States

Ellen R. Goldman

Center for Bio/Molecular Science and Engineering, Naval Research Laboratory, Washington, District of Columbia, United States