2-({3-[(2R,4S,5R)-4-Hydroxy-5-hydroxymethyl-2,3,4,5-tetrahydrofuran-2-yl]-5-methyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-1-yl}methyl)isoindoline-1,3-dione

Abstract

The title compound, C19H19N3O7, is a thymidine derivative and serves as an intermediate in the synthesis of a 99mTc radiolabeled nucleoside analog. Intermolecular O—H...O hydrogen bonding is observed between the hydroxy functionalities of the ribose unit themselves as well as between a hydroxy group and an O atom of the phthalimide group of an adjacent molecule. The molecules are stacked on top of each other in the direction of the a axis. The crystal packing is further stabilized by weak intra- and intermolecular C—H...O hydrogen bonds. The absolute configuration of the compound is known from the synthesis.