DUB1 suppresses Hippo signaling by modulating TAZ protein expression in gastric cancer

Dehai Wang; Zhongbo Li; Xin Li; Cheng Yan; Huijie Yang; Ting Zhuang; Xiao Wang; Yifeng Zang; Ziping Liu; Tianshi Wang; Rixia Jiang; Peng Su; Jian Zhu; Yinlu Ding

doi:10.1186/s13046-022-02410-5

Journal of Experimental & Clinical Cancer Research (Jul 2022)

DUB1 suppresses Hippo signaling by modulating TAZ protein expression in gastric cancer

Dehai Wang,
Zhongbo Li,
Xin Li,
Cheng Yan,
Huijie Yang,
Ting Zhuang,
Xiao Wang,
Yifeng Zang,
Ziping Liu,
Tianshi Wang,
Rixia Jiang,
Peng Su,
Jian Zhu,
Yinlu Ding

Affiliations

Dehai Wang: Department of General Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University
Zhongbo Li: Xinxiang Key Laboratory of Tumor Migration and Invasion Precision Medicine, School of Laboratory Medicine, Xinxiang Medical University
Xin Li: Xinxiang Key Laboratory of Tumor Migration and Invasion Precision Medicine, School of Laboratory Medicine, Xinxiang Medical University
Cheng Yan: School of Medicine, Xinxiang University
Huijie Yang: Xinxiang Key Laboratory of Tumor Migration and Invasion Precision Medicine, School of Laboratory Medicine, Xinxiang Medical University
Ting Zhuang: Xinxiang Key Laboratory of Tumor Migration and Invasion Precision Medicine, School of Laboratory Medicine, Xinxiang Medical University
Xiao Wang: Department of Burns and Plastic Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University
Yifeng Zang: Department of General Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University
Ziping Liu: Department of General Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University
Tianshi Wang: Department of General Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University
Rixia Jiang: Department of Hepatobiliary Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University
Peng Su: Department of Pathology, Shandong University Qilu Hospital, Cheeloo College of Medicine, Shandong University
Jian Zhu: Department of General Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University
Yinlu Ding: Department of General Surgery, The Second Hospital, Cheeloo College of Medicine, Shandong University

DOI: https://doi.org/10.1186/s13046-022-02410-5
Journal volume & issue: Vol. 41, no. 1
pp. 1 – 17

Abstract

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Highlights 1. DUB1 is an important modulator of Hippo signaling in gastric cancer. 2. DUB1 expression is elevated in human gastric cancer samples and correlates with poor survival in gastric cancer. 3. DUB1 facilitates gastric cancer progression via the Hippo/TAZ axis. 4. DUB1 associates with TAZ and directly inhibits YAP polyubiquitination and degradation.

Published in Journal of Experimental & Clinical Cancer Research

ISSN: 1756-9966 (Online)
Publisher: BMC
Country of publisher: United Kingdom
LCC subjects: Medicine: Internal medicine: Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Website: https://jeccr.biomedcentral.com/

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Abstract

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