Nature Communications (Nov 2021)

MOFs-based nanoagent enables dual mitochondrial damage in synergistic antitumor therapy via oxidative stress and calcium overload

  • Weier Bao,
  • Ming Liu,
  • Jiaqi Meng,
  • Siyuan Liu,
  • Shuang Wang,
  • Rongrong Jia,
  • Yugang Wang,
  • Guanghui Ma,
  • Wei Wei,
  • Zhiyuan Tian

DOI
https://doi.org/10.1038/s41467-021-26655-4
Journal volume & issue
Vol. 12, no. 1
pp. 1 – 17

Abstract

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Targeting damage to mitochondria has become an effective strategy antitumor therapies. Here, the authors report on nanoagents with upconversion nanoparticles as cores and photoacid-loaded MOFs as shells for NIR triggered Fenton reaction, acidification and calcium overload to provide synergistic mitochondrial damage.