Nature Communications (Jun 2022)
Perirenal adipose afferent nerves sustain pathological high blood pressure in rats
- Peng Li,
- Boxun Liu,
- Xiaoguang Wu,
- Yan Lu,
- Ming Qiu,
- Yihui Shen,
- Yunfan Tian,
- Chi Liu,
- Xiru Chen,
- Chuanxi Yang,
- Mengqing Deng,
- Yaqing Wang,
- Jia Gu,
- Zhongping Su,
- Xuguan Chen,
- Kun Zhao,
- Yanhui Sheng,
- Shijiang Zhang,
- Wei Sun,
- Xiangqing Kong
Affiliations
- Peng Li
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
- Boxun Liu
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
- Xiaoguang Wu
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
- Yan Lu
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
- Ming Qiu
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
- Yihui Shen
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
- Yunfan Tian
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
- Chi Liu
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
- Xiru Chen
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
- Chuanxi Yang
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
- Mengqing Deng
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
- Yaqing Wang
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
- Jia Gu
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
- Zhongping Su
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
- Xuguan Chen
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
- Kun Zhao
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
- Yanhui Sheng
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
- Shijiang Zhang
- Cardiovascular Device and Technique Engineering Laboratory of Jiangsu Province
- Wei Sun
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
- Xiangqing Kong
- Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University
- DOI
- https://doi.org/10.1038/s41467-022-30868-6
- Journal volume & issue
-
Vol. 13,
no. 1
pp. 1 – 13
Abstract
The sympathetic nervous system can contribute to the development of hypertension, but the neurogenic mechanisms involved are incompletely understood. Here the authors report that afferent nerves in the perirenal adipose tissue (PRAT) contribute to the maintenance of high blood pressure, and PRAT ablation, denervation or upregulation of calcitonin gene-related peptide reduce blood pressure in hypertensive rats.
