Nature Communications (Oct 2021)
Germline determinants of humoral immune response to HPV-16 protect against oropharyngeal cancer
- Aida Ferreiro-Iglesias,
- James D. McKay,
- Nicole Brenner,
- Shama Virani,
- Corina Lesseur,
- Valerie Gaborieau,
- Andy R. Ness,
- Rayjean J. Hung,
- Geoffrey Liu,
- Brenda Diergaarde,
- Andrew F. Olshan,
- Neil Hayes,
- Mark C. Weissler,
- Lea Schroeder,
- Noemi Bender,
- Michael Pawlita,
- Steve Thomas,
- Miranda Pring,
- Tom Dudding,
- Beatriz Kanterewicz,
- Robert Ferris,
- Sera Thomas,
- Yonathan Brhane,
- Virginia Díez-Obrero,
- Maja Milojevic,
- Karl Smith-Byrne,
- Daniela Mariosa,
- Mattias J. Johansson,
- Rolando Herrero,
- Stefania Boccia,
- Gabriella Cadoni,
- Martin Lacko,
- Ivana Holcátová,
- Wolfgang Ahrens,
- Pagona Lagiou,
- Areti Lagiou,
- Jerry Polesel,
- Lorenzo Simonato,
- Franco Merletti,
- Claire M. Healy,
- Bo T. Hansen,
- Mari Nygård,
- David I. Conway,
- Sylvia Wright,
- Tatiana V. Macfarlane,
- Max Robinson,
- Laia Alemany,
- Antonio Agudo,
- Ariana Znaor,
- Christopher I. Amos,
- Tim Waterboer,
- Paul Brennan
Affiliations
- Aida Ferreiro-Iglesias
- Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization
- James D. McKay
- Section of Genetics, Genetic Cancer Susceptibility Group, International Agency for Research on Cancer, World Health Organization
- Nicole Brenner
- Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Shama Virani
- Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization
- Corina Lesseur
- Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization
- Valerie Gaborieau
- Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization
- Andy R. Ness
- National Institute for Health Research (NIHR) Bristol Biomedical Research Centre, University Hospitals Bristol and Weston NHS Foundation Trust and the University of Bristol
- Rayjean J. Hung
- Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System
- Geoffrey Liu
- Lunenfeld-Tanenbaum Research Institute of Sinai Health System, University of Toronto
- Brenda Diergaarde
- Department of Human Genetics, Graduate School of Public Health, University of Pittsburgh
- Andrew F. Olshan
- Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina at Chapel Hill
- Neil Hayes
- Division of Medical Oncology and Center for Cancer Research, University of Tennessee Health Science Center
- Mark C. Weissler
- Department of Otolaryngology/Head and Neck Surgery, University of North Carolina at Chapel Hill, Chapel Hill
- Lea Schroeder
- Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Noemi Bender
- Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Michael Pawlita
- Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Steve Thomas
- Bristol Dental School, University of Bristol
- Miranda Pring
- Bristol Dental School, University of Bristol
- Tom Dudding
- Bristol Dental School, University of Bristol
- Beatriz Kanterewicz
- UPMC Hillman Cancer Center
- Robert Ferris
- UPMC Hillman Cancer Center
- Sera Thomas
- Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System
- Yonathan Brhane
- Prosserman Centre for Population Health Research, Lunenfeld-Tanenbaum Research Institute, Sinai Health System
- Virginia Díez-Obrero
- Oncology Data Analytics Program, Catalan Institute of Oncology (ICO)
- Maja Milojevic
- Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization
- Karl Smith-Byrne
- Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization
- Daniela Mariosa
- Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization
- Mattias J. Johansson
- Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization
- Rolando Herrero
- Section of Early Detection and Prevention, Prevention and Implementation Group, International Agency for Research on Cancer, World Health Organization
- Stefania Boccia
- Section of Hygiene, University Department of Life Sciences and Public Health, Università Cattolica del Sacro Cuore
- Gabriella Cadoni
- Department of Head and Neck Surgery, Institute of Clinical Otorhinolaryngology, Università Cattolica del Sacro Cuore
- Martin Lacko
- Department of Otorhinolaryngology, Head and Neck Surgery, Maastricht University Medical Center
- Ivana Holcátová
- Institute of Hygiene and Epidemiology
- Wolfgang Ahrens
- University Bremen
- Pagona Lagiou
- School of Medicine, National and Kapodistrian University of Athens
- Areti Lagiou
- School of Public Health, University of West Attica
- Jerry Polesel
- National Cancer Institute, IRCCS
- Lorenzo Simonato
- University of Padova
- Franco Merletti
- CeRMS and University of Turin
- Claire M. Healy
- Trinity College School of Dental Science
- Bo T. Hansen
- Cancer Registry of Norway
- Mari Nygård
- Department of Research, Cancer Registry of Norway
- David I. Conway
- School of Medicine, Dentistry, and Nursing, University of Glasgow
- Sylvia Wright
- Queen Elizabeth University Hospital, NHS Greater Glasgow and Clyde
- Tatiana V. Macfarlane
- University of Aberdeen
- Max Robinson
- Centre for Oral Health Research, Newcastle University
- Laia Alemany
- Catalan Institute of Oncology/IDIBELL
- Antonio Agudo
- Catalan Institute of Oncology/IDIBELL
- Ariana Znaor
- Cancer Surveillance Section, International Agency for Research on Cancer, World Health Organization
- Christopher I. Amos
- Department of Medicine, Baylor College of Medicine
- Tim Waterboer
- Infections and Cancer Epidemiology, German Cancer Research Center (DKFZ)
- Paul Brennan
- Section of Genetics, Genetic Epidemiology Group, International Agency for Research on Cancer, World Health Organization
- DOI
- https://doi.org/10.1038/s41467-021-26151-9
- Journal volume & issue
-
Vol. 12,
no. 1
pp. 1 – 11
Abstract
Genetic susceptibility loci for oropharyngeal cancer have been reported but these studies have not always examined human papillomavirus (HPV) status. Here, the authors perform genome-wide analysis taking into account HPV16 serology status and report two independent loci in the HLA region, suggesting the protective role of HLA variants against HPV infection.
