Higher NAFLD fibrosis score is associated with impaired eGFR

Meng-Hsuan Hsieh; Kuan-Ta Wu; Yi-Yu Chen; Jeng-Fu Yang; Wen-Yi Lin; Ning-Chia Chang; Chia-Yi Lin; Chao-Kuan Huang; Chao-Ling Wang; Hung-Yi Chuang; Shu-Ching Lin; Yu-Kuei Hsu; Yi-Shan Tsai; Wan-Long Chuang; Ming-Lung Yu; Chia-Yen Dai

Journal of the Formosan Medical Association (Jan 2020)

Higher NAFLD fibrosis score is associated with impaired eGFR

Meng-Hsuan Hsieh,
Kuan-Ta Wu,
Yi-Yu Chen,
Jeng-Fu Yang,
Wen-Yi Lin,
Ning-Chia Chang,
Chia-Yi Lin,
Chao-Kuan Huang,
Chao-Ling Wang,
Hung-Yi Chuang,
Shu-Ching Lin,
Yu-Kuei Hsu,
Yi-Shan Tsai,
Wan-Long Chuang,
Ming-Lung Yu,
Chia-Yen Dai

Affiliations

Meng-Hsuan Hsieh: Health Management Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC; Department of Occupational and Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC; Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; Hepatobiliary Section, Department of Internal Medicine, and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan, ROC
Kuan-Ta Wu: Health Management Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC
Yi-Yu Chen: Health Management Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC
Jeng-Fu Yang: Health Management Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC
Wen-Yi Lin: Department of Occupational Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Taiwan, ROC
Ning-Chia Chang: Department of Occupational Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Taiwan, ROC
Chia-Yi Lin: Health Examination Center, Kaohsiung Municipal Ta-Tung Hospital, Kaohsiung, Taiwan, ROC
Chao-Kuan Huang: Department of Occupational Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Taiwan, ROC
Chao-Ling Wang: Department of Occupational and Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC
Hung-Yi Chuang: Department of Occupational and Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC
Shu-Ching Lin: Health Management Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC
Yu-Kuei Hsu: Health Management Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC
Yi-Shan Tsai: Hepatobiliary Section, Department of Internal Medicine, and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC
Wan-Long Chuang: Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; Hepatobiliary Section, Department of Internal Medicine, and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC
Ming-Lung Yu: Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; Hepatobiliary Section, Department of Internal Medicine, and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan, ROC; Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan, ROC; Corresponding author. Hepatobiliary Section, Department of Internal Medicine, and Hepatitis Center, Kaohsiung Medical University Hospital, 100, Tzyou 1st Road, Kaohsiung, 807, Taiwan, ROC.
Chia-Yen Dai: Health Management Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC; Department of Occupational and Environmental Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC; Faculty of Internal Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan, ROC; Hepatobiliary Section, Department of Internal Medicine, and Hepatitis Center, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, ROC; Institute of Biomedical Sciences, National Sun Yat-Sen University, Kaohsiung, Taiwan, ROC; Department of Biological Science and Technology, College of Biological Science and Technology, National Chiao Tung University, Hsin-Chu, Taiwan, ROC; Corresponding author. Hepatobiliary Section, Department of Internal Medicine, and Hepatitis Center, Kaohsiung Medical University Hospital, 100, Tzyou 1st Road, Kaohsiung, 807, Taiwan, ROC.

Journal volume & issue: Vol. 119, no. 1
pp. 496 – 503

Abstract

Read online

Background/Purpose: Chronic kidney disease (CKD) has become a worldwide health problem, leading to high morbidity and mortality, and non-alcoholic fatty liver disease (NAFLD) is considered a risk factor for CKD. The aim of this study was to explore the relationship between NAFLD fibrosis score (NFS) and the estimated glomerular filtration rate (eGFR), and identify possible risk factors related to the NFS among Taiwanese subjects. Methods: Subjects were enrolled from the database of the Department of Preventive Medicine of Kaohsiung Municipal Hsiao-Kang Hospital. The eGFR was calculated according to the Taiwanese Modification of Diet in Renal Disease (TMDRD) equation, and the NFS was employed to evaluate the fibrotic level. Results: In total, 11,376 subjects were enrolled in this study, with a mean age of 52.0 ± 6.81 years, including 4529 (39.8%) males. A fasting sugar level ≥100 mg/dL (OR = 1.70, 95% CI = 1.52–1.87) and an abnormal waist circumference (OR = 1.81, 95% CI = 1.65–1.99) were significant factors associated with NFS (p < 0.05). Trends of a decreasing TMDRD score and an increasing NFS with increasing age were noted (p < 0.05). The NFS was significantly negatively correlated with the TMDRD score (standard coefficients: −0.067, p < 0.001). Conclusion: A higher NFS is associated with an impaired eGFR in Taiwanese subjects. Controlling risk factors, especially fasting sugar level and waist circumference, may be useful in preventing NFS deterioration, which is negatively correlated with the eGFR. Keywords: NAFLD fibrosis score, Estimated glomerular filtration rate, Fasting sugar, Waist circumference

Published in Journal of the Formosan Medical Association

ISSN: 0929-6646 (Print)
Publisher: Elsevier
Country of publisher: Netherlands
LCC subjects: Medicine: Medicine (General)
Website: http://www.journals.elsevier.com/journal-of-the-formosan-medical-association/

About the journal