Nature Communications (Oct 2016)

Endoglin integrates BMP and Wnt signalling to induce haematopoiesis through JDP2

  • June Baik,
  • Alessandro Magli,
  • Naoyuki Tahara,
  • Scott A. Swanson,
  • Naoko Koyano-Nakagawa,
  • Luciene Borges,
  • Ron Stewart,
  • Daniel J. Garry,
  • Yasuhiko Kawakami,
  • James A. Thomson,
  • Rita C. R. Perlingeiro

DOI
https://doi.org/10.1038/ncomms13101
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 11

Abstract

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How both BMP and Wnt signalling pathways regulate lineage specification early in development is unclear. Here, the authors show that endoglin via Jdp2, an AP-1 family member, modulates BMP and Wnt signalling to commit mesodermal progenitors to a haematopoietic fate at the expense of the cardiac lineage.