Nature Communications (Mar 2016)
Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4
Abstract
The Tec family tyrosine kinase, Itk, is a component of the T-cell receptor essential for optimal Th2 responses in vivo. Here the authors show in human cells and mouse models that Itk is also needed for the production of IL-9, an important contributor to allergic asthma.