Nature Communications (Mar 2016)

Itk is required for Th9 differentiation via TCR-mediated induction of IL-2 and IRF4

  • Julio Gomez-Rodriguez,
  • Françoise Meylan,
  • Robin Handon,
  • Erika T. Hayes,
  • Stacie M. Anderson,
  • Martha R. Kirby,
  • Richard M. Siegel,
  • Pamela L. Schwartzberg

DOI
https://doi.org/10.1038/ncomms10857
Journal volume & issue
Vol. 7, no. 1
pp. 1 – 15

Abstract

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The Tec family tyrosine kinase, Itk, is a component of the T-cell receptor essential for optimal Th2 responses in vivo. Here the authors show in human cells and mouse models that Itk is also needed for the production of IL-9, an important contributor to allergic asthma.