Pyroptosis: A new frontier in cancer

Yuan Fang; Shengwang Tian; Yutian Pan; Wei Li; Qiming Wang; Yu Tang; Tao Yu; Xi Wu; Yongkang Shi; Pei Ma; Yongqian Shu

Biomedicine & Pharmacotherapy (Jan 2020)

Pyroptosis: A new frontier in cancer

Yuan Fang,
Shengwang Tian,
Yutian Pan,
Wei Li,
Qiming Wang,
Yu Tang,
Tao Yu,
Xi Wu,
Yongkang Shi,
Pei Ma,
Yongqian Shu

Affiliations

Yuan Fang: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of China
Shengwang Tian: Department of Medical Oncology, Affiliated Jintan Hospital of Jiangsu University, Changzhou 213200, People’s Republic of China
Yutian Pan: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of China
Wei Li: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of China; Department of Oncology, Affiliated Sir Run Run Hospital of Nanjing Medical University, Nanjing 211166, People’s Republic of China
Qiming Wang: Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of China
Yu Tang: Department of Cardio-Thoracic Surgery, Affiliated Nanjing Hospital of Nanjing Medical University, Nanjing 210006, People’s Republic of China
Tao Yu: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of China
Xi Wu: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of China
Yongkang Shi: Department of Medical Oncology, Affiliated Jintan Hospital of Jiangsu University, Changzhou 213200, People’s Republic of China
Pei Ma: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of China; Corresponding authors at: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People’s Republic of China.
Yongqian Shu: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, People’s Republic of China; Department of Medical Oncology, Affiliated Jintan Hospital of Jiangsu University, Changzhou 213200, People’s Republic of China; Department of Oncology, Affiliated Sir Run Run Hospital of Nanjing Medical University, Nanjing 211166, People’s Republic of China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Personalized Medicine, Nanjing Medical University, Nanjing 211166, People’s Republic of China; Corresponding authors at: Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, People’s Republic of China.

Journal volume & issue: Vol. 121
p. 109595

Abstract

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Pyroptosis is an inflammatory form of cell death triggered by certain inflammasomes, leading to the cleavage of gasdermin D (GSDMD) and activation of inactive cytokines like IL-18 and IL-1β. Pyroptosis has been reported to be closely associated to some diseases like atherosclerosis and diabetic nephropathy. Recently, some studies found that pyroptosis can influence the proliferation, invasion and metastasis of tumor, which regulated by some non-coding RNAs and other molecules. Hence, we provided an overview of morphological and molecular characteristics of pyroptosis. We also focus on mechanism of regulating pyroptosis in tumor cells as well as the potential roles of pyroptosis in cancer to explore potential diagnostic markers in cancers contributing to the prevention and treatment in cancers.

Published in Biomedicine & Pharmacotherapy

ISSN: 0753-3322 (Print); 1950-6007 (Online)
Publisher: Elsevier
Country of publisher: France
LCC subjects: Medicine: Therapeutics. Pharmacology
Website: https://www.journals.elsevier.com/biomedicine-and-pharmacotherapy

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