BMC Cardiovascular Disorders (Jan 2022)

Level of advanced oxidation protein products is associated with subclinical atherosclerosis

  • Zsolt Bagyura,
  • Angéla Takács,
  • Loretta Kiss,
  • Edit Dósa,
  • Réka Vadas,
  • Tin Dat Nguyen,
  • Elek Dinya,
  • Pál Soós,
  • Zsolt Szelid,
  • Orsolya Láng,
  • Éva Pállinger,
  • László Kőhidai,
  • Béla Merkely

DOI
https://doi.org/10.1186/s12872-021-02451-2
Journal volume & issue
Vol. 22, no. 1
pp. 1 – 9

Abstract

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Abstract Background Oxidative stress is an important factor in the pathomechanism of atherosclerosis. Advanced oxidation protein products (AOPPs) are considered markers of oxidative stress. Thickening of the carotid intima-media layers indicates subclinical atherosclerosis and can be detected by carotid ultrasound. Objective Our aim was to examine the association between carotid intima-media thickness (CIMT) and the level of AOPPs. Methods Carotid duplex scans and measurements of AOPPs were performed on 476 participants of a cardiovascular population study. The presence of conventional cardiovascular risk factors was investigated with a questionnaire, physical examination, and laboratory tests. Results There was a positive correlation between maximum CIMT and the level of AOPPs only in the male population (r = 0.219, p = 0.033). Multivariate analysis has revealed that the association between AOPPs and mean or maximum CIMT was independent of cardiovascular risk factors (OR = 1.458, p = 0.004, and OR = 2.038, p < 0.001). Conclusions Among males, the elevated level of AOPPs as a marker of oxidative stress may signal the existence of early atherosclerotic alterations.

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