Nature Communications (Jan 2019)
Lsd1 as a therapeutic target in Gfi1-activated medulloblastoma
- Catherine Lee,
- Vasilisa A. Rudneva,
- Serap Erkek,
- Marc Zapatka,
- Lianne Q. Chau,
- Silvia K. Tacheva-Grigorova,
- Alexandra Garancher,
- Jessica M. Rusert,
- Ozlem Aksoy,
- Robin Lea,
- Helai P. Mohammad,
- Jianxun Wang,
- William A. Weiss,
- H. Leighton Grimes,
- Stefan M. Pfister,
- Paul A. Northcott,
- Robert J. Wechsler-Reya
Affiliations
- Catherine Lee
- Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- Vasilisa A. Rudneva
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- Serap Erkek
- Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
- Marc Zapatka
- Division of Molecular Genetics, German Cancer Research Center (DKFZ)
- Lianne Q. Chau
- Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- Silvia K. Tacheva-Grigorova
- Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- Alexandra Garancher
- Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- Jessica M. Rusert
- Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- Ozlem Aksoy
- Department of Neurology, University of California
- Robin Lea
- Department of Neurology, University of California
- Helai P. Mohammad
- Cancer Epigenetics DPU, GlaxoSmithKline
- Jianxun Wang
- College of Life Sciences, Beijing University of Chinese Medicine
- William A. Weiss
- Department of Neurology, University of California
- H. Leighton Grimes
- Division of Immunobiology and Center for Systems Immunology, Cincinnati Children’s Hospital Medical Center
- Stefan M. Pfister
- Hopp Children’s Cancer Center at the NCT Heidelberg (KiTZ)
- Paul A. Northcott
- Department of Developmental Neurobiology, St. Jude Children’s Research Hospital
- Robert J. Wechsler-Reya
- Tumor Initiation and Maintenance Program, NCI-Designated Cancer Center, Sanford Burnham Prebys Medical Discovery Institute
- DOI
- https://doi.org/10.1038/s41467-018-08269-5
- Journal volume & issue
-
Vol. 10,
no. 1
pp. 1 – 13
Abstract
Medulloblastoma is one of the most prevalent malignant brain tumors in children and has very poor prognosis. In this study, the authors show, using a mouse model of medulloblastoma, that Gfi1 promotes tumor growth by recruiting Lsd1, that this interaction inhibits genes involved in neuronal differentiation, and that Lsd1 may be a therapeutic target in Gfi1-activated tumors.
