Oral microbial extracellular DNA initiates periodontitis through gingival degradation by fibroblast-derived cathepsin K in mice

Takeru Kondo; Hiroko Okawa; Akishige Hokugo; Bhumika Shokeen; Oskar Sundberg; Yiying Zheng; Charles E. McKenna; Renate Lux; Ichiro Nishimura

doi:10.1038/s42003-022-03896-7

Communications Biology (Sep 2022)

Oral microbial extracellular DNA initiates periodontitis through gingival degradation by fibroblast-derived cathepsin K in mice

Takeru Kondo,
Hiroko Okawa,
Akishige Hokugo,
Bhumika Shokeen,
Oskar Sundberg,
Yiying Zheng,
Charles E. McKenna,
Renate Lux,
Ichiro Nishimura

Affiliations

Takeru Kondo: Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry
Hiroko Okawa: Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry
Akishige Hokugo: Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry
Bhumika Shokeen: Section of Biosystems and Function, UCLA School of Dentistry
Oskar Sundberg: Department of Chemistry, Dana and David Dornsife College of Letters, Arts and Sciences, University of Southern California
Yiying Zheng: Department of Chemistry, Dana and David Dornsife College of Letters, Arts and Sciences, University of Southern California
Charles E. McKenna: Department of Chemistry, Dana and David Dornsife College of Letters, Arts and Sciences, University of Southern California
Renate Lux: Section of Biosystems and Function, UCLA School of Dentistry
Ichiro Nishimura: Weintraub Center for Reconstructive Biotechnology, Division of Regenerative & Reconstructive Sciences, UCLA School of Dentistry

DOI: https://doi.org/10.1038/s42003-022-03896-7
Journal volume & issue: Vol. 5, no. 1
pp. 1 – 14

Abstract

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A highly sensitive imaging probe shows that oral microbial extracellular DNA triggers early activity of Ctsk in gingival fibroblasts, initiating periodontitis in mice.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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