Nature Communications (Jul 2020)

Neuroligin 2 regulates absence seizures and behavioral arrests through GABAergic transmission within the thalamocortical circuitry

  • Feng Cao,
  • Jackie J. Liu,
  • Susan Zhou,
  • Miguel A. Cortez,
  • O. Carter Snead,
  • Jing Han,
  • Zhengping Jia

DOI
https://doi.org/10.1038/s41467-020-17560-3
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 15

Abstract

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Neuroligins are postsynaptic cell adhesion molecules that are involved in synapse function and autism spectrum disorder. The authors show that NLG2-mediated GABAergic transmission at the thalamic reticular nucleus-thalamic circuit is a common mechanism underlying epileptic seizures and ASD.