Formulation and characterization of liposomal glutathione as a key component in mitigation of Kwashiorkor disease in children with malnutrition

Abstract

Background. Kwashiorkor disease is due to deficiency of protein in malnutrition condition. Malnutrition is one of the major drawbacks among the Indian children. In India, the impact of undernutrition among impoverished children is disproportionately felt in rural areas. Due to the unequal distribution of food within the household and the consumption of foods with low nutritional qualities, increases the percent of malnutrition in children. Objective. To formulate liposomal glutathione as a potent high antioxidant agent for delivery nutritional effect in nutraceutical formulations and other food supplements for boosting immunity through combating Kwashiorkor disease during malnutrition condition in children. Method. Nanoliposome of glutathione was formulated by ethanol injection method via formation of organic and aqueous phases. Further, morphology of the formulated liposomal glutathione was characterized using cryo-TEM and confirmed for suitability in nutraceuticals as immune enhancers in children. Result. Glutathione was successfully entrapped in lipid as nanoformulations. Cyro-TEM analysis resulted the shape of the particles are spherical with 0.1 µM average diameter. Conclusion. The overall result concluded that liposomal glutathione is very effective in formulation of nutraceutical as well as food supplements as potent immune booster for children and reduce protein deficiency in malnutrition to cure Kwashiorkor disease.

Keywords

• cryo-tem
• glutathione
• nanofoumulation
• nutraceuticals