Journal of Pharmacological Sciences (May 2016)

Intravenous anti-influenza drug oseltamivir will not induce torsade de pointes: Evidences from proarrhythmia model and action-potential assay

  • Yuji Nakamura,
  • Rieko Sasaki,
  • Xin Cao,
  • Takeshi Wada,
  • Shogo Hamaguchi,
  • Hiroko Izumi-Nakaseko,
  • Kentaro Ando,
  • Hikaru Tanaka,
  • Akira Takahara,
  • Atsushi Sugiyama

DOI
https://doi.org/10.1016/j.jphs.2016.04.018
Journal volume & issue
Vol. 131, no. 1
pp. 72 – 75

Abstract

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We evaluated proarrhythmic risk of intravenous oseltamivir with chronic atrioventricular block canine model (n = 4) and action-potential assay on guinea-pig right ventricle (n = 5). Oseltamivir in doses of 3–30 mg/kg, i.v. did not induce torsade de pointes in the canine model, whereas that in concentrations of 30–300 μM decreased maximum rate of phase 0 depolarization, shortened action potential duration at 30%, 60% and 90% repolarization levels, but prolonged difference in action-potential duration between 30% and 90% repolarization levels in a concentration-related manner. These results indicate that oseltamivir will not induce torsade de pointes clinically, since it inhibits both inward and outward currents.

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