Exacerbation of adverse cardiovascular effects of aircraft noise in an animal model of arterial hypertension
Sebastian Steven,
Katie Frenis,
Sanela Kalinovic,
Miroslava Kvandova,
Matthias Oelze,
Johanna Helmstädter,
Omar Hahad,
Konstantina Filippou,
Kamil Kus,
Chiara Trevisan,
Klaus-Dieter Schlüter,
Kerstin Boengler,
Stefan Chlopicki,
Katrin Frauenknecht,
Rainer Schulz,
Mette Sorensen,
Andreas Daiber,
Swenja Kröller-Schön,
Thomas Münzel
Affiliations
Sebastian Steven
Center for Cardiology, Cardiology I – Laboratory of Molecular Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany; Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany
Katie Frenis
Center for Cardiology, Cardiology I – Laboratory of Molecular Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany
Sanela Kalinovic
Center for Cardiology, Cardiology I – Laboratory of Molecular Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany
Miroslava Kvandova
Center for Cardiology, Cardiology I – Laboratory of Molecular Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany
Matthias Oelze
Center for Cardiology, Cardiology I – Laboratory of Molecular Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany
Johanna Helmstädter
Center for Cardiology, Cardiology I – Laboratory of Molecular Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany
Omar Hahad
Center for Cardiology, Cardiology I – Laboratory of Molecular Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany
Konstantina Filippou
Center for Cardiology, Cardiology I – Laboratory of Molecular Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany
Kamil Kus
Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Poland
Chiara Trevisan
Institute of Neuropathology, University Hospital, Zurich, Switzerland
Klaus-Dieter Schlüter
Department of Physiology, Justus-Liebig University Gießen, Germany
Kerstin Boengler
Department of Physiology, Justus-Liebig University Gießen, Germany
Stefan Chlopicki
Jagiellonian Centre for Experimental Therapeutics (JCET), Jagiellonian University, Krakow, Poland; Chair of Pharmacology, Jagiellonian University Medical College, Krakow, Poland
Katrin Frauenknecht
Institute of Neuropathology, University Hospital, Zurich, Switzerland
Rainer Schulz
Department of Physiology, Justus-Liebig University Gießen, Germany
Mette Sorensen
Danish Cancer Society, Copenhagen, Denmark; Department of Natural Science and Environment, Roskilde University, Roskilde, Denmark
Andreas Daiber
Center for Cardiology, Cardiology I – Laboratory of Molecular Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany; Corresponding authors. Center for Cardiology, Cardiology I – Laboratory of Molecular Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Swenja Kröller-Schön
Center for Cardiology, Cardiology I – Laboratory of Molecular Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany
Thomas Münzel
Center for Cardiology, Cardiology I – Laboratory of Molecular Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany; German Center for Cardiovascular Research (DZHK), Partner Site Rhine-Main, Mainz, Germany; Corresponding authors. Center for Cardiology, Cardiology I – Laboratory of Molecular Cardiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany.
Arterial hypertension is the most important risk factor for the development of cardiovascular disease. Recently, aircraft noise has been shown to be associated with elevated blood pressure, endothelial dysfunction, and oxidative stress. Here, we investigated the potential exacerbated cardiovascular effects of aircraft noise in combination with experimental arterial hypertension. C57BL/6J mice were infused with 0.5 mg/kg/d of angiotensin II for 7 days, exposed to aircraft noise for 7 days at a maximum sound pressure level of 85 dB(A) and a mean sound pressure level of 72 dB(A), or subjected to both stressors. Noise and angiotensin II increased blood pressure, endothelial dysfunction, oxidative stress and inflammation in aortic, cardiac and/or cerebral tissues in single exposure models. In mice subjected to both stressors, most of these risk factors showed potentiated adverse changes. We also found that mice exposed to both noise and ATII had increased phagocytic NADPH oxidase (NOX-2)-mediated superoxide formation, immune cell infiltration (monocytes, neutrophils and T cells) in the aortic wall, astrocyte activation in the brain, enhanced cytokine signaling, and subsequent vascular and cerebral oxidative stress. Exaggerated renal stress response was also observed. In summary, our results show an enhanced adverse cardiovascular effect between environmental noise exposure and arterial hypertension, which is mainly triggered by vascular inflammation and oxidative stress. Mechanistically, noise potentiates neuroinflammation and cerebral oxidative stress, which may be a potential link between both risk factors. The results indicate that a combination of classical (arterial hypertension) and novel (noise exposure) risk factors may be deleterious for cardiovascular health.
