Circulating tumor cells in head and neck cancer: A review

Kyle P. McMullen; Jeffrey J. Chalmers; Jas C. Lang; Pawan Kumar; Kris R. Jatana

World Journal of Otorhinolaryngology-Head and Neck Surgery (Jun 2016)

Circulating tumor cells in head and neck cancer: A review

Kyle P. McMullen,
Jeffrey J. Chalmers,
Jas C. Lang,
Pawan Kumar,
Kris R. Jatana

Affiliations

Kyle P. McMullen: Department of Otolaryngology-Head and Neck Surgery, Wexner Medical Center at Ohio State University, Columbus, OH, USA
Jeffrey J. Chalmers: William G. Lowrie Department of Chemical and Biomolecular Engineering, Ohio State University, Columbus, OH, USA
Jas C. Lang: Department of Otolaryngology-Head and Neck Surgery, Wexner Medical Center at Ohio State University, Columbus, OH, USA
Pawan Kumar: Department of Otolaryngology-Head and Neck Surgery, Wexner Medical Center at Ohio State University, Columbus, OH, USA
Kris R. Jatana: Department of Otolaryngology-Head and Neck Surgery, Wexner Medical Center at Ohio State University, Columbus, OH, USA; Department of Pediatric Otolaryngology-Head & Neck Surgery, Nationwide Children's Hospital, Columbus, OH, USA; Corresponding author. Department of Otolaryngology-Head and Neck Surgery, Nationwide Children's Hospital, 555 South 18th Street, Suite 2A, Columbus, OH 43205, USA. Tel.: +1 614 722 6600; fax: +1 614 722 6609.

Journal volume & issue: Vol. 2, no. 2
pp. 109 – 116

Abstract

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Carcinoma of the head and neck represents 3.5% of all cancers, and the vast majority of these tumors are squamous cell carcinoma (HNSCC). With a stable overall survival rate of 50% among all stages, there is continued interested in developing measures for early detection and disease aggressiveness. Circulating tumor cells (CTCs) have been identified as a potential marker for early metastatic disease, response to treatment, and surveillance in head and neck squamous cell carcinoma. In this article, techniques of CTC detection, applications of CTC technology, and outcomes of HNSCC patients will be discussed. Keywords: Circulating tumor cell, Metastasis, Head and neck cancer, Squamous cell

Published in World Journal of Otorhinolaryngology-Head and Neck Surgery

ISSN: 2095-8811 (Print); 2589-1081 (Online)
Publisher: Wiley
Country of publisher: United Kingdom
LCC subjects: Medicine: Otorhinolaryngology; Medicine: Surgery
Website: https://onlinelibrary.wiley.com/journal/25891081

About the journal