Nature Communications (Jul 2020)
Preferential inhibition of adaptive immune system dynamics by glucocorticoids in patients after acute surgical trauma
- Edward A. Ganio,
- Natalie Stanley,
- Viktoria Lindberg-Larsen,
- Jakob Einhaus,
- Amy S. Tsai,
- Franck Verdonk,
- Anthony Culos,
- Sajjad Ghaemi,
- Kristen K. Rumer,
- Ina A. Stelzer,
- Dyani Gaudilliere,
- Eileen Tsai,
- Ramin Fallahzadeh,
- Benjamin Choisy,
- Henrik Kehlet,
- Nima Aghaeepour,
- Martin S. Angst,
- Brice Gaudilliere
Affiliations
- Edward A. Ganio
- Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University
- Natalie Stanley
- Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University
- Viktoria Lindberg-Larsen
- The Lundbeck Foundation Center for Fast-track Hip and Knee replacement
- Jakob Einhaus
- Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University
- Amy S. Tsai
- Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University
- Franck Verdonk
- Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University
- Anthony Culos
- Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University
- Sajjad Ghaemi
- Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University
- Kristen K. Rumer
- Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University
- Ina A. Stelzer
- Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University
- Dyani Gaudilliere
- Division of Plastic and Reconstructive Surgery, Department of Surgery, School of Medicine, Stanford University
- Eileen Tsai
- Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University
- Ramin Fallahzadeh
- Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University
- Benjamin Choisy
- Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University
- Henrik Kehlet
- Section of Surgical Pathophysiology 7621, Rigshospitalet
- Nima Aghaeepour
- Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University
- Martin S. Angst
- Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University
- Brice Gaudilliere
- Department of Anesthesiology, Perioperative and Pain Medicine, School of Medicine, Stanford University
- DOI
- https://doi.org/10.1038/s41467-020-17565-y
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 12
Abstract
Glucocorticoids (GC) are commonly used to suppress undesirable inflammatory responses. Here the authors show, using hi-dimensional flow cytometry data, that GC treatment following major surgeries alters adaptive immunity without significant modulation of innate immune responses or pain/functional impairment.
