Association of Blood Cell-Derived Inflammatory Markers with Symptoms and Short-Term Treatment Response in Late-Life Depression

Abstract

Meixu Lu,1 Yan Zhang,2 Leiming Shi,2 Qianlong Wang,1 Xiaohua Yang,2 Haitao Ma,2 Mingzhen Wang,2 Yuping Zhao,2 Qi Miao2 1School of Mental Health, Jining Medical University, Jining, People’s Republic of China; 2Shandong Mental Health Center (Affiliated Mental Health Center of Shandong University), Shandong Provincial Key Medical and Health Discipline of Gerontology (Shandong Mental Health Center), Jinan, Shandong, People’s Republic of ChinaCorrespondence: Qi Miao, Shandong Mental Health Center (Affiliated Mental Health Center of Shandong University), Shandong Provincial Key Medical and Health Discipline of Gerontology (Shandong Mental Health Center), Jinan, Shandong, 250014, People’s Republic of China, Email [email protected]: The aim of this study was to explore the relationship between whole blood cell-derived inflammatory markers and clinical symptoms in patients with late-life depression (LLD). It also aimed to explore the predictive value of whole blood cell-derived inflammatory markers on the efficacy of short-term medication.Methods: Eighty-three patients with LLD were included, and their baseline demographics, routine blood test results and clinical characteristics before and after 2 weeks of treatment were collected. Whole-blood cell-derived inflammatory markers at pre-treatment were calculated. Additionally, correlation analysis was used to explore the correlation between inflammatory makers and clinical characteristics. Multivariable logistic regression was used to analyze the factors influencing short-term outcomes in patients. The predictive value of whole blood cell-derived inflammatory markers for short-term outcomes was evaluated by plotting receiver operating characteristic (ROC) curve.Results: In this study, baseline PLR showed a positive correlation with the patients’ HAMA scores at baseline. Furthermore, the levels of NLR, MLR, and NPR at baseline were negatively correlated with the patients’ percentage reduction in HAMD score after 2 weeks of treatment. Regression analysis showed that baseline NPR was an independent risk factor affecting the efficacy of short-term pharmacological treatment. ROC curve analysis showed that the area under the curve of baseline NPR for predicting the outcome of short-term treatment was 0.713.Conclusion: There is a correlation between baseline whole blood cell-derived inflammatory markers and anxiety symptoms and short-term antidepressant efficacy in patients with LLD. Pre-treatment NPR levels may be an independent risk factor influencing the short-term treatment outcome in patients with LLD, and it may have a potential predictive value for short-term treatment efficacy.Keywords: late-life depression, inflammatory biomarker, short-term outcome prediction, predictive value

Keywords

• late-life depression
• Inflammatory biomarker
• short-term outcome prediction
• predictive value