Фармакокинетика и Фармакодинамика (Sep 2016)

Comparative study of the trimetazidine and fabomotizole hydrochloride сardioprotective effect in rats with established alcoholic cardiomyopathy with the continued ethanol consumption

  • I. B. Tsorin,
  • I. A. Miroshkina,
  • E. O. Ionova,
  • A. V. Nadorova,
  • V. N. Stolyaruk,
  • M. B. Vititnova,
  • A. V. Sorokina,
  • L. G. Kolik,
  • A. D. Durnev,
  • S. A. Kryzhanovskii

Journal volume & issue
Vol. 0, no. 3
pp. 38 – 41

Abstract

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In the previousLy deveLoped transLation modeL of aLcohoLic cardiomyopathy in white nonLinear rats was studied the cardioprotective effects of trimetazidine and fabomotizoLe hydrochLoride that were injected daiLy during the 25th - 28th weeks of continued consumption of 10% ethanoL It is shown that trimetazidine (30 mg/kg/day i.p.) and fabomotizoLe hydrochLoride (15 mg/kg / day i.p/) in the above conditions, significantLy reduced the remodeLing of the Left and right ventricLes of the heart and increased the heart contractiLe function.

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