Rosai-Dorfman Disease Presenting as Recurrent Nasal Polyposis

Abstract

Objective: To present a case of Rosai-Dorfman disease in an individual with a 14-year history of recurrent nasal polyposis, and discuss its clinical presentation, physical examination, radiologic findings, histopathologic characteristics, and available treatment. Methods: Design: Case Report Setting: Tertiary Private Hospital Patient: One Result: A 26-year-old Filipino diagnosed and repeatedly treated medically and surgically for recurrent nasal polyposis underwent repeat endoscopic sinus surgery. A histopathologic impression of Rosai-Dorfman disease was confirmed by positive S-100 and CD1a negative immunochemistry in conjunction with the morphologic findings. Conclusion: Rosai-Dorfman disease is a rare entity which should be considered when dealing with recurrent nasal polyposis that is intractable to initial medical and surgical therapies. Histopathologic findings of emperipolesis and immunohistochemical S-100 stains play a key role in the diagnosis, but there is yet no definite treatment for this disease. Keywords: recurrent nasal polyposis, Rosai-Dorfman disease, emperipolesis, S-100 stain

Keywords

• recurrent nasal polyposis, Rosai-Dorfman disease, emperipolesis, S-100 stain