Frontiers in Aging Neuroscience (Oct 2014)

Improving CSF biomarkers’ performance for predicting progression from Mild Cognitive Impairment to Alzheimer’s disease: a meta-analysis

  • Daniel eFerreira,
  • Amado eRivero-Santana,
  • Lilisbeth ePerestelo-Perez,
  • Eric eWestman,
  • Lars-Olof eWahlund,
  • Antonio eSarria-Santamera,
  • Pedro Guillermo Serrano-Aguilar

DOI
https://doi.org/10.3389/fnagi.2014.00287
Journal volume & issue
Vol. 6

Abstract

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Background: CSF biomarkers’ performance for predicting conversion from mild cognitive impairment (MCI) to Alzheimer disease (AD) is still suboptimal. Objective: By considering several confounding factors we aimed to identify in which situations these CSF biomarkers can be useful. Data sources: A systematic review was conducted on MEDLINE, PreMedline, EMBASE, PsycInfo, CINAHL, Cochrane, and CRD (1990-2013). Eligibility criteria: 1) prospective studies of CSF biomarkers’ performance for predicting conversion from MCI to AD/dementia; 2) inclusion of Aß42 and T-tau and/or p-tau. Several meta-analyses were performed. Results: Aß42/p-tau ratio had high capacity to predict conversion to AD in MCI patients younger than 70 years. P-tau had high capacity to identify MCI cases converting to AD in ≤24 months. Conclusions: Explaining how different confounding factors influence CSF biomarkers’ predictive performance is mandatory to elaborate a definitive map of situations where these CSF biomarkers are useful both in clinics and research.

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