Frontiers in Public Health (May 2023)

Disseminated tuberculosis and diagnosis delay during the COVID-19 era in a Western European country: a case series analysis

  • Sílvia Roure,
  • Sílvia Roure,
  • Sílvia Roure,
  • Xavier Vallès,
  • Xavier Vallès,
  • Xavier Vallès,
  • Xavier Vallès,
  • Nieves Sopena,
  • Nieves Sopena,
  • Rosa Maria Benítez,
  • Rosa Maria Benítez,
  • Esteban A. Reynaga,
  • Esteban A. Reynaga,
  • Carmen Bracke,
  • Carmen Bracke,
  • Cora Loste,
  • Cora Loste,
  • Lourdes Mateu,
  • Lourdes Mateu,
  • Adrián Antuori,
  • Tania Baena,
  • Germán Portela,
  • Judith Llussà,
  • Clara Flamarich,
  • Laura Soldevila,
  • Laura Soldevila,
  • Montserrat Tenesa,
  • Montserrat Tenesa,
  • Ricard Pérez,
  • Elsa Plasencia,
  • Jordi Bechini,
  • Jordi Bechini,
  • Maria Lluïsa Pedro-Botet,
  • Maria Lluïsa Pedro-Botet,
  • Maria Lluïsa Pedro-Botet,
  • Maria Lluïsa Pedro-Botet,
  • Bonaventura Clotet,
  • Bonaventura Clotet,
  • Cristina Vilaplana,
  • Cristina Vilaplana,
  • Cristina Vilaplana,
  • Cristina Vilaplana,
  • Cristina Vilaplana

DOI
https://doi.org/10.3389/fpubh.2023.1175482
Journal volume & issue
Vol. 11

Abstract

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BackgroundDisseminated tuberculosis is frequently associated with delayed diagnosis and a poorer prognosis.ObjectivesTo describe case series of disseminated TB and diagnosis delay in a low TB burden country during the COVID-19 period.MethodologyWe consecutively included all patients with of disseminated TB reported from 2019 to 2021 in the reference hospital of the Northern Crown of the Metropolitan Area of Barcelona. We collected socio-demographic information, clinical, laboratory and radiological findings.ResultsWe included all 30 patients reported during the study period—5, 9, and 16 in 2019, 2020, and 2021 respectively—20 (66.7%) of whom were male and whose mean age was 41 years. Twenty-five (83.3%) were of non-EU origin. The most frequent system involvement was central nervous system (N = 8; 26.7%) followed by visceral (N = 7; 23.3%), gastro-intestinal (N = 6, 20.0%), musculoskeletal (N = 5; 16.7%), and pulmonary (N = 4; 13.3%). Hypoalbuminemia and anemia were highly prevalent (72 and 77%). The median of diagnostic delay was 6.5 months (IQR 1.8–30), which was higher among women (36.0 vs. 3.5 months; p = 0.002). Central nervous system involvement and pulmonary involvement were associated with diagnostic delay among women. We recorded 24 cured patients, two deaths, three patients with post-treatment sequelae, and one lost-to-follow up. We observed a clustering effect of patients in low-income neighborhoods (p < 0.001).ConclusionThere was a substantial delay in the diagnosis of disseminated TB in our study region, which might impacted the prognosis with women affected more negatively. Our results suggest that an increase in the occurrence of disseminated TB set in motion by diagnosis delay may have been a secondary effect of the COVID-19 pandemic.

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